(-)-1-benzylideneamino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile

Base Information

• Chemical Name: (-)-1-benzylideneamino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile
• CAS No.: 155385-82-3
• Molecular Formula: C₁₉H₂₁N₃
• Molecular Weight: 291.396
• Mol file: 155385-82-3.mol

Synonyms:(-)-1-benzylideneamino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile

Chemical Property of (-)-1-benzylideneamino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-1-benzylideneamino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile

There total 2 articles about (-)-1-benzylideneamino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

benzaldehyde (100-52-7) + (-)-1-amino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1,3R-dicarbonitrile (155385-79-8) → (-)-1-benzylideneamino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile (155385-82-3)

Guidance literature:

With sodium sulfate; In chloroform; for 20h; Heating;

Reference yield:

(-)-(1R,2R,5R)-2-methyl-5-(1-methylethenyl)-3-oxocyclohexanecarbonitrile (137625-67-3) → (-)-1-benzylideneamino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile (155385-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride / aq. NH₃; H₂O; methanol / 24 h

2: 73 percent / Na₂SO₄ / CHCl₃ / 20 h / Heating

With ammonium chloride; sodium sulfate; In methanol; ammonium hydroxide; chloroform; water;

Reference yield: 96.0%

ethyl Phenylphosphinate (172487-18-2,2511-09-3) + (-)-1-benzylideneamino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile (155385-82-3) → ethyl {[(1R,2R,3R,5R)-1,3-dicyano-5-(1-methylethenyl)-2-methylcyclohexylamino]-phenyl-methyl}phenylphosphinate

Guidance literature:

at 50 - 70 ℃; for 20h;

DOI:10.1016/j.tetasy.2008.03.013

upstream raw materials:

benzaldehyde

(-)-1-amino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1,3R-dicarbonitrile

(-)-(1R,2R,5R)-2-methyl-5-(1-methylethenyl)-3-oxocyclohexanecarbonitrile

Downstream raw materials:

(-)-1S-<(cyano phenyl methyl)amino>-2R-methyl-5R-(1-methylethenyl)-cyclohexane-1R,3R-dicarbonitrile

L-phenylglycine amide

(R)-phenylglycine amide