Technology Process of phosphoric acid mono-{(2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl}ester
There total 8 articles about phosphoric acid mono-{(2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydropyran-2-ylmethyl}ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
amberlyst 15 ion exchange resin;
In
methanol;
Reflux;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C
2.1: trifluoroacetic acid; trifluorormethanesulfonic acid; triethylsilane / 0.42 h / 20 °C
3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 1 h / -78 °C
3.2: 1 h / -78 °C
3.3: 16 h / 20 °C
4.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 4 h / 10 °C
5.1: dmap; pyridine / dichloromethane / 2 h / 20 °C
6.1: tricyclohexylphosphine; potassium phosphate / toluene; water / 0.75 h
6.2: Reflux
7.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol
8.1: 1H-tetrazole / dichloromethane; tetrahydrofuran / 0.42 h / 0 - 20 °C
8.2: 2 h / -40 - 20 °C
9.1: amberlyst 15 ion exchange resin / methanol / Reflux
With
pyridine; 1H-tetrazole; triethylsilane; dmap; aluminum (III) chloride; potassium phosphate; n-butyllithium; lithium hydroxide monohydrate; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; trifluoroacetic acid; tricyclohexylphosphine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C
2.1: aluminum (III) chloride / dichloromethane / 0 - 20 °C
3.1: trifluoroacetic acid; trifluorormethanesulfonic acid; triethylsilane / 0.42 h / 20 °C
4.1: n-butyllithium / toluene; hexane; tetrahydrofuran / 1 h / -78 °C
4.2: 1 h / -78 °C
4.3: 16 h / 20 °C
5.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 4 h / 10 °C
6.1: dmap; pyridine / dichloromethane / 2 h / 20 °C
7.1: tricyclohexylphosphine; potassium phosphate / toluene; water / 0.75 h
7.2: Reflux
8.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol
9.1: 1H-tetrazole / dichloromethane; tetrahydrofuran / 0.42 h / 0 - 20 °C
9.2: 2 h / -40 - 20 °C
10.1: amberlyst 15 ion exchange resin / methanol / Reflux
With
pyridine; 1H-tetrazole; triethylsilane; dmap; aluminum (III) chloride; potassium phosphate; n-butyllithium; oxalyl dichloride; lithium hydroxide monohydrate; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; trifluoroacetic acid; tricyclohexylphosphine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
![phosphoric acid di-tert-butyl ester (2R,3S,4R,5R,6S)-6-[3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-4-ethyl-phenyl]-3,4,5-trihydroxy-tetrahydro-pyran-2-ylmethyl ester](/Databaselist/images/loading.webp)
