α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-6-phenylhexyl>benzenepropanamide

Base Information

Chemical Name:α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-6-phenylhexyl>benzenepropanamide
CAS No.:137650-44-3
Molecular Formula:C₂₄H₃₄N₂O₂*ClH
Molecular Weight:419.007
Hs Code.:

Synonyms:α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-6-phenylhexyl>benzenepropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-6-phenylhexyl>benzenepropanamide

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Technology Process of α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-6-phenylhexyl>benzenepropanamide

There total 10 articles about α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-6-phenylhexyl>benzenepropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(S)-2-(4-Hydroxy-2,6-dimethyl-phenyl)-1-((R)-1-methyl-6-phenyl-hexylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 137650-44-3
α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-6-phenylhexyl>benzenepropanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 23 ℃; for 0.166667h; Yield given;
DOI:10.1021/jm00080a005

Reference yield:

: 5581-76-0
6-phenyl-hexanoic acid methyl ester

: 137650-44-3
α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-6-phenylhexyl>benzenepropanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / Dibal-H / CH₂Cl₂; toluene / 0.25 h / -78 °C

2: 93 percent / 60 °C

3: 40 percent / CeCl₃ / tetrahydrofuran / -78 - 23 °C

4: 78 percent / H₂ / Raney nickel / methanol / 60 °C / 20685.9 Torr

5: 4-methylmorpholine / CH₂Cl₂ / 1.5 h

6: 6.5N HCl / dioxane; CH₂Cl₂ / 0.17 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; cerium(III) chloride; hydrogen; diisobutylaluminium hydride; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1021/jm00080a005

Reference yield:

: 18328-11-5
3-benzyl propionaldehyde

: 137650-44-3
α(S)-amino-4-hydroxy-2,6-dimethyl-N-<1(R)-methyl-6-phenylhexyl>benzenepropanamide

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) THF, 0 deg C, 0.5 h, 2.) THF, 15 min

2: 98 percent / H₂ / Pd/C / methanol / 258.6 Torr

3: 94 percent / Dibal-H / CH₂Cl₂; toluene / 0.25 h / -78 °C

4: 93 percent / 60 °C

5: 40 percent / CeCl₃ / tetrahydrofuran / -78 - 23 °C

6: 78 percent / H₂ / Raney nickel / methanol / 60 °C / 20685.9 Torr

7: 4-methylmorpholine / CH₂Cl₂ / 1.5 h

8: 6.5N HCl / dioxane; CH₂Cl₂ / 0.17 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; cerium(III) chloride; hydrogen; sodium hydride; diisobutylaluminium hydride; palladium on activated charcoal; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1021/jm00080a005