(R)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methanamine

Base Information

• Chemical Name: (R)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methanamine
• CAS No.: 103883-30-3
• Molecular Formula: C6H13 N O2
• Molecular Weight: 131.175
• Hs Code.: 2932990090
• European Community (EC) Number: 866-061-8
• Mol file: 103883-30-3.mol

Synonyms:103883-30-3;(R)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methanamine;[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methanamine;1,3-Dioxolane-4-methanamine, 2,2-dimethyl-, (4R)-;(R)-4-Aminomethyl-2,2-dimethyl-1,3-dioxolane;MFCD02262087;[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methanamine;(R)-(-)-(2,2-Dimethyl-[1,3]-dioxolan-4-yl)methylamine;(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanamine;1,3-Dioxolane-4-methanamine,2,2-dimethyl-,(4R)-;SCHEMBL3862320;HXOYWCSTHVTLOW-RXMQYKEDSA-N;GEO-01180;AKOS005257688;CS-W005528;DS-3132;AC-28996;(R)-2,2-dimethyl-1,3-dioxolane-4-methanamine;EN300-2956231;W-200073;C-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methylamine

Chemical Property of (R)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methanamine

Chemical Property:

• Vapor Pressure: 1.587mmHg at 25°C
• Refractive Index: 1.43
• Boiling Point: 168.847°C at 760 mmHg
• PKA: 9.16±0.29(Predicted)
• Flash Point: 57.552°C
• PSA: 44.48000
• Density: 0.979g/cm³
• LogP: 0.79690
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

97% ^*data from raw suppliers

(R)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41-43
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(OCC(O1)CN)C
• Isomeric SMILES: CC1(OC[C@H](O1)CN)C

Technology Process of (R)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methanamine

There total 2 articles about (R)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(R)-2-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]isoindoline-1,3-dione → (R)-(-)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)methylamine (103883-30-3,96894-67-6)

Guidance literature:

With water; hydrazine; In methanol; Reflux;

DOI:10.1002/chem.201905745

Reference yield:

1,2-O-isopropylidene-D-glycerol (14347-78-5,36543-79-0) → (R)-(-)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)methylamine (103883-30-3,96894-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 h / 20 °C

2: water; hydrazine / methanol / Reflux

With water; triphenylphosphine; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1002/chem.201905745

Reference yield: 82.0%

(R)-(-)-(2,2-dimethyl-[1,3]-dioxolan-4-yl)methylamine (103883-30-3,96894-67-6) + 1,5-difluoro-2,4-dinitrobenzene (327-92-4) → N-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-5-fluoro-2,4-dinitroaniline

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

1,2-O-isopropylidene-D-glycerol