327-92-4

Basic information

• Product Name: 1,5-Difluoro-2,4-dinitrobenzene
• Synonyms: FFDNB;5-Fluoro-2-Nitroanline;1,3-Difluoro-4,6-Dinitrobenzene/1,5-Difluoro-2,4-Dinitrobenzene;1,5-Difluoro-2,4-dinitrobenzene97%;1,5-DIFLUORO-2,4-DINITROBENZENE 99+%;1,3-Dinitro-4,6-difluorobenzene;4,6-Dinitro-1,3-difluorobenzene;4,6-Dinitro-1,3-phenylene difluoride
• CAS NO: 327-92-4
• Molecular Formula: C₆H₂F₂N₂O₄
• Molecular Weight: 204.09
• EINECS: 206-324-0
• Product Categories: Aromatic Halides (substituted);Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 327-92-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 72-74 °C(lit.)
• Boiling Point: 306.8 °C at 760 mmHg
• Flash Point: 139.4 °C
• Appearance: light yellow to light brown crystalline powder
• Density: 1.6930 (estimate)
• Vapor Pressure: 228mmHg at 25°C
• Refractive Index: 1.374
• Storage Temp.: Store below +30°C.
• Solubility: soluble in Methanol
• Water Solubility: insoluble
• BRN: 1883116
• CAS DataBase Reference: 1,5-Difluoro-2,4-dinitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Difluoro-2,4-dinitrobenzene(327-92-4)
• EPA Substance Registry System: 1,5-Difluoro-2,4-dinitrobenzene(327-92-4)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-33-38
• Safety Statements: 36/37/39-45-36/37-28A-28
• RIDADR: UN 2811 6.1/PG 1
• WGK Germany: 3
• RTECS: CZ5663200
• F: 10-21
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 327-92-4(Hazardous Substances Data)

Usage

Chemical Properties

light yellow to light brown crystalline powder

InChI:InChI=1/C3H4ClF/c1-3(4)2-5/h1-2H2

Upstream product

• 3698-83-7 2,4-dichloro-1,5-dinitrobenzene 
• 446-35-5 2,4-Difluoronitrobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 327-91-3 2-fluoro-4-chloro-1,3,5-trinitrobenzene 
• 148854-10-8 (2,4-difluorophenyl)trimethylsilane 

Downstream Products

• 1210-96-4 1,3-dimethoxy-4,6-dinitrobenzene 
• 105337-28-8 1,5-dinitro-2,4-dipropoxy-benzene 
• 102007-50-1 1,5-dinitro-2,4-bis-p-tolyloxy-benzene 
• 346-48-5 N-(5-fluoro-2,4-dinitro-phenyl)-alanine 
• 100876-90-2 1,5-diisobutoxy-2,4-dinitrobenzene 
• 101270-57-9 1,5-dinitro-2,4-bis-pentyloxy-benzene 
• 102442-05-7 1,5-dinitro-2,4-bis-(1-phenyl-ethoxy)-benzene 
• 1827-18-5 N-chloroacetyl-O-(5-fluoro-2,4-dinitro-phenyl)-L-tyrosine ethyl ester 
• 65944-09-4 N,N'-bis-chloroacetyl-O,O'-(4,6-dinitro-m-phenylene)-di-L-tyrosine diethyl ester 
• 2873-62-3 N¹,N³-dimethyl-4,6-dinitrobenzene-1,3-diamine 
• 735-61-5 N-(5-fluoro-2,4-dinitro-phenyl)-glycine ethyl ester 
• 4987-96-6 1,3-diamino-4,6-dinitrobenzene 
• 2253-30-7 1,3-dichloro-4,6-difluorobenzene 
• 367-81-7 2,4-dinitro-5-fluoroaniline 

Relevant articles and documents

Preparation method of fluorine-containing aryl compound

The invention relates to the field of organic synthesis, and especially relates to a preparation method of a fluorine-containing aryl compound. The invention provides a preparation method of a compound as shown in a formula 1. The preparation method comprises the following steps: fluorination reaction: reacting a compound as shown in a formula 2 with alkali metal fluoride in the presence of a phase transfer catalyst to prepare the compound as shown in the formula 1. According to the preparation method of the fluorine-containing aryl compound provided by the invention, a reaction system does not contain a solvent, the boiling point of the phase transfer catalyst is relatively high, solvent interference is avoided during rectification or short steaming after the reaction is finished, the distillation yield is high, and the product purity is good.

Method of preparing 1,5-difluoro-2,4-dinitrobenzene

The invention discloses a method of preparing 1,5-difluoro-2,4-dinitrobenzene. According to the method, 1,5-difluoro-2,4-dinitrobenzene is prepared via nitration in a concentrated sulfuric acid and fuming nitric acid mixed system by taking m-difluorobenzene as a starting raw material. A synthesis process is very simple and convenient; reaction conditions are mild; the raw material is cheap and easy to obtain; fewer byproducts are generated in a preparation process; the productivity is higher; a product with higher purity can be obtained without recrystallization operation; and industrial production can be performed.

Production method of flumioxazin

The invention discloses a production method of flumioxazin. The production method comprises the following steps: by using 2,4-difluoronitrobenzene as an initial raw material, sequentially carrying out nitrification to obtain 1,5-difluoro-2,4-dinitrobenzene, and carrying out etherification reaction on the 1,5-difluoro-2,4-dinitrobenzene and butyl hydroxyacetate to obtain butyl 3-fluoro-4,6-dinitrophenoxyacetate; carrying out reduction cyclization with hydrogen to obtain 7-fluoro-6-amino-2H-1,4-benzoxazinyl-3(4H)-one; under alkaline conditions, carrying out alkynylation reaction with propargyl chloride to obtain an intermediate product; and finally, carrying out amidation reaction with 3,4,5,6-tetrahydrophthalic anhydride to obtain the flumioxazin. The production technique of the method has the advantages of short process, mild reaction conditions and cheap and accessible raw materials, and is convenient to operate; and the solvent used in the preparation process is recyclable. The method also has the advantages of high total reaction yield, high product purity, low production cost and low environmental pollution.