3-[2'-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-biphenyl-4-ylmethyl]-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

Base Information

• Chemical Name: 3-[2'-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-biphenyl-4-ylmethyl]-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester
• CAS No.: 1026321-00-5
• Molecular Formula: C₃₇H₄₂N₂O₇
• Molecular Weight: 626.75
• Mol file: 1026321-00-5.mol

Synonyms:3-[2'-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-biphenyl-4-ylmethyl]-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

Chemical Property of 3-[2'-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-biphenyl-4-ylmethyl]-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2'-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-biphenyl-4-ylmethyl]-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

There total 9 articles about 3-[2'-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-biphenyl-4-ylmethyl]-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Chloromethyl pivalate (18997-19-8) + 3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester (172876-23-2) → 3-[2'-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-biphenyl-4-ylmethyl]-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester (1026321-00-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; at 20 - 50 ℃; for 3h;

DOI:10.1021/jm950450f

Reference yield:

2-propyl-1H-imidazole-4,5-dicarboxylic acid (58954-23-7) → 3-[2'-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-biphenyl-4-ylmethyl]-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester (1026321-00-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 86 percent / HCl / Ambient temperature

2: 95 percent / diethyl ether; CH₂Cl₂ / 1 h / 10 - 15 °C

3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

4: 100 percent / LiOH*H₂O / dioxane; H₂O / 20 h / Ambient temperature

5: 96 percent / K₂CO₃ / N,N-dimethyl-acetamide / 3 h / 20 - 50 °C

6: 100 percent / HCl / dioxane / 16 h / Ambient temperature

7: 100 percent / K₂CO₃ / N,N-dimethyl-acetamide / 3 h / 20 - 50 °C

With hydrogenchloride; lithium hydroxide; potassium tert-butylate; potassium carbonate; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl acetamide; water;

DOI:10.1021/jm950450f

Reference yield:

4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester (114772-40-6) → 3-[2'-(2,2-Dimethyl-propionyloxymethoxycarbonyl)-biphenyl-4-ylmethyl]-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester (1026321-00-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

2: 100 percent / LiOH*H₂O / dioxane; H₂O / 20 h / Ambient temperature

3: 96 percent / K₂CO₃ / N,N-dimethyl-acetamide / 3 h / 20 - 50 °C

4: 100 percent / HCl / dioxane / 16 h / Ambient temperature

5: 100 percent / K₂CO₃ / N,N-dimethyl-acetamide / 3 h / 20 - 50 °C

With hydrogenchloride; lithium hydroxide; potassium tert-butylate; potassium carbonate; In 1,4-dioxane; N,N-dimethyl acetamide; water;

DOI:10.1021/jm950450f

upstream raw materials:

Chloromethyl pivalate

3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

2-propyl-1H-imidazole-4,5-dicarboxylic acid

4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester