3'-N-(N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys)-Dox

Base Information

• Chemical Name: 3'-N-(N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys)-Dox
• CAS No.: 84624-22-6
• Molecular Formula: C₇₄H₈₁N₅O₁₈
• Molecular Weight: 1328.48
• Mol file: 84624-22-6.mol

Synonyms:3'-N-(N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys)-Dox

Chemical Property of 3'-N-(N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys)-Dox

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3'-N-(N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys)-Dox

There total 1 articles about 3'-N-(N^α-Fmoc-D-Val-Leu-N^ε-Fmoc-Lys)-Dox which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(9-fluorenylmethoxycarbonyl)-D-valine (84624-17-9) → 3'-N-(Nα-Fmoc-D-Val-Leu-Nε-Fmoc-Lys)-Dox (84624-22-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 55 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBT*H₂O), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 14 h / 0 - 25 °C

2: 98 percent / 27percent HBr / acetic acid / 3 h / Ambient temperature

3: 52 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBT*H₂O), 1-ethyl-3<3-(dimethylamino)propyl>carbodiimine hydrochloride / dimethylformamide / 14 h / 0 - 25 °C

4: 95 percent / 27percent HBr / acetic acid / 2.5 h / 25 °C

5: N-methylmorpholine, isobutylchloroformate / 1.) DMF, -15 deg, 2 h, 2.) RT, 12 h

With 4-methyl-morpholine; hydrogen bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; isobutyl chloroformate; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00359a004

upstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-D-valine