1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

Base Information

• Chemical Name: 1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester
• CAS No.: 144876-64-2
• Molecular Formula: C₂₀H₃₁NO₄Si
• Molecular Weight: 377.556

Synonyms:1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

Chemical Property of 1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of 1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

There total 3 articles about 1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-(Trimethylsilyl)ethanol (2916-68-9) + 1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid (17191-43-4) → 1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester (144876-64-2)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; acetonitrile; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

1-aminocyclohexane carboxylic acid (2756-85-6) → 1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester (144876-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent

2: 68 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / acetonitrile; dimethylformamide / 24 h / Ambient temperature

With dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester (144876-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent

2: 68 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / acetonitrile; dimethylformamide / 24 h / Ambient temperature

With dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/S0040-4020(01)86596-0

upstream raw materials:

2-(Trimethylsilyl)ethanol

1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid

1-aminocyclohexane carboxylic acid

benzyl chloroformate

Downstream raw materials:

1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

2-(trimethylsilyl)ethyl-1-isocyanato-1-cyclohexane carboxylate

<10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-pentaazaspiro<5,13>nonadecane-17-acetic acid

methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate

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