erythro-2,3-dibromo-3-phenylpropanol

Base Information

• Chemical Name: erythro-2,3-dibromo-3-phenylpropanol
• CAS No.: 83263-29-0
• Molecular Formula: C₉H₁₀Br₂O
• Molecular Weight: 293.986
• Mol file: 83263-29-0.mol

Synonyms:erythro-2,3-dibromo-3-phenylpropanol

Chemical Property of erythro-2,3-dibromo-3-phenylpropanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythro-2,3-dibromo-3-phenylpropanol

There total 8 articles about erythro-2,3-dibromo-3-phenylpropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2E)-3-phenyl-2-propen-1-ol (4407-36-7) → rac-(2R,3S)-2,3-dibromo-3-phenylpropan-1-ol (36808-12-5,83263-29-0,142052-64-0)

Guidance literature:

With 4-dimethylaminopyridine tribromide; In acetic acid; for 0.25h; Ambient temperature;

Reference yield: 92.0%

(2E)-3-phenyl-2-propen-1-ol (4407-36-7) → erythro-2-bromo-3-hydroxy-3-phenylpropan-1-ol (18652-74-9,18652-75-0,36808-14-7) + rac-(2R,3S)-2,3-dibromo-3-phenylpropan-1-ol (36808-12-5,83263-29-0,142052-64-0)

Guidance literature:

With Oxone; ammonium bromide; In water; acetonitrile; at 20 ℃; for 0.05h; stereoselective reaction;

DOI:10.1016/j.tetlet.2012.01.026

Reference yield: 86.0%

3-Phenylpropenol (104-54-1) → rac-(2R,3S)-2,3-dibromo-3-phenylpropan-1-ol (36808-12-5,83263-29-0,142052-64-0)

Guidance literature:

With dihydrogen peroxide; acetic acid; lithium bromide; In 1,4-dioxane; at 20 ℃; for 6h; stereoselective reaction;

DOI:10.1039/c7nj04300g

upstream raw materials:

(2E)-3-phenyl-2-propen-1-ol

3-Phenylpropenol

(E)-3-phenylpropenal

2-phenoxy-1-phenylpropane-1, 3-diol

Downstream raw materials:

acetimidic acid-((2RS,3SR)-2,3-dibromo-3-phenyl-propyl ester)

(2RS,3RS)-3-amino-3-phenyl-propane-1,2-diol

(2RS,3SR)-3-bromo-3-phenyl-1,2-epoxypropane

(2E)-3-phenyl-2-propen-1-ol

Refernces

• 1、 Rossa, Thaís A.,Fantinel, Mariane,Bortoluzzi, Adailton J.,Sá, Marcus M.. "Multicomponent Synthesis of Structurally Diverse Imidazoles Featuring Azirines, Amines and Aldehydes". supporting information. p. 4171 - 4177. Retrieved 2018/08/21.
• 2、 Landry, Matthew L.,Hu, Dennis X.,McKenna, Grace M.,Burns, Noah Z.. "Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (-)-Deschloromytilipin A and (-)-Danicalipin A". supporting information. p. 5150 - 5158. Retrieved 2016/05/19.