(+)-(S)-S-Methyl-S-phenyl-N-(3-p-tosyloxypropyl)sulfoximine

Base Information

• Chemical Name: (+)-(S)-S-Methyl-S-phenyl-N-(3-p-tosyloxypropyl)sulfoximine
• CAS No.: 210552-38-8
• Molecular Formula: C₁₇H₂₁NO₄S₂
• Molecular Weight: 367.49
• Mol file: 210552-38-8.mol

Synonyms:(+)-(S)-S-Methyl-S-phenyl-N-(3-p-tosyloxypropyl)sulfoximine

Chemical Property of (+)-(S)-S-Methyl-S-phenyl-N-(3-p-tosyloxypropyl)sulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(S)-S-Methyl-S-phenyl-N-(3-p-tosyloxypropyl)sulfoximine

There total 2 articles about (+)-(S)-S-Methyl-S-phenyl-N-(3-p-tosyloxypropyl)sulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

p-toluenesulfonyl chloride (98-59-9) + (+)-(S)-N-(3-Hydroxypropyl)-S-methyl-S-phenylsulfoximine (210552-36-6) → (+)-(S)-S-Methyl-S-phenyl-N-(3-p-tosyloxypropyl)sulfoximine (210552-38-8)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 20h;

DOI:10.1055/s-1998-2071

Reference yield:

(S)-S-methyl-S-phenylsulfoximine (4381-25-3,33903-50-3,60933-65-5,81162-81-4) → (+)-(S)-S-Methyl-S-phenyl-N-(3-p-tosyloxypropyl)sulfoximine (210552-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / KH, Bu₄NBr / 1,2-dimethoxy-ethane / 1.) 25 deg C, 3 h, 2.) 25 deg C, 20 h

2: 92 percent / NEt₃ / CH₂Cl₂ / 20 h / 25 °C

With tetrabutylammomium bromide; potassium hydride; triethylamine; In 1,2-dimethoxyethane; dichloromethane;

DOI:10.1055/s-1998-2071

Reference yield: 57.0%

(+)-(S)-S-Methyl-S-phenyl-N-(3-p-tosyloxypropyl)sulfoximine (210552-38-8) → (+)-(S)-1-Phenyl-3,4,5,6-tetrahydro[1,2]thiazin-1-oxide (210552-40-2)

Guidance literature:

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexane; at 25 ℃; for 20h;

DOI:10.1055/s-1998-2071

upstream raw materials:

p-toluenesulfonyl chloride

(+)-(S)-N-(3-Hydroxypropyl)-S-methyl-S-phenylsulfoximine

(S)-S-methyl-S-phenylsulfoximine

Downstream raw materials:

(+)-(S)-1-Phenyl-3,4,5,6-tetrahydro[1,2]thiazin-1-oxide