2-tert-butyl-4,4,8,8-tetramethyl-3-p-methoxyphenyl-1,6-dioxa-2,9-diazaspiro[4.4]nonane

Base Information

Chemical Name:2-tert-butyl-4,4,8,8-tetramethyl-3-p-methoxyphenyl-1,6-dioxa-2,9-diazaspiro[4.4]nonane
CAS No.:642481-73-0
Molecular Formula:C₂₀H₃₂N₂O₃
Molecular Weight:348.486
Hs Code.:

Synonyms:2-tert-butyl-4,4,8,8-tetramethyl-3-p-methoxyphenyl-1,6-dioxa-2,9-diazaspiro[4.4]nonane

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Chemical Property of 2-tert-butyl-4,4,8,8-tetramethyl-3-p-methoxyphenyl-1,6-dioxa-2,9-diazaspiro[4.4]nonane

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Technology Process of 2-tert-butyl-4,4,8,8-tetramethyl-3-p-methoxyphenyl-1,6-dioxa-2,9-diazaspiro[4.4]nonane

There total 1 articles about 2-tert-butyl-4,4,8,8-tetramethyl-3-p-methoxyphenyl-1,6-dioxa-2,9-diazaspiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 34575-25-2
4,4-Dimethyl-2-(1-methylethyl)-4,5-dihydrooxazole

: 127896-00-8,40117-28-0
(Z)-N-tert-butyl-1-(4-methoxyphenyl)methanimine oxide

: 642481-73-0
2-tert-butyl-4,4,8,8-tetramethyl-3-p-methoxyphenyl-1,6-dioxa-2,9-diazaspiro[4.4]nonane

Guidance literature:: 4,4-Dimethyl-2-(1-methylethyl)-4,5-dihydrooxazole; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h;

(Z)-N-tert-butyl-1-(4-methoxyphenyl)methanimine oxide; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃;
DOI:10.1021/jo035356i

Reference yield: 34.0%

: 642481-73-0
2-tert-butyl-4,4,8,8-tetramethyl-3-p-methoxyphenyl-1,6-dioxa-2,9-diazaspiro[4.4]nonane

: 642481-77-4
2-tert-butyl-4,4-dimethyl-3-p-methoxyphenylisoxazolidin-5-one

Guidance literature:: With water; trifluoroacetic acid; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jo035356i

Reference yield:

: 642481-73-0
2-tert-butyl-4,4,8,8-tetramethyl-3-p-methoxyphenyl-1,6-dioxa-2,9-diazaspiro[4.4]nonane

: 3-tert-butylamino-2,2-dimethyl-3-p-methoxyphenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 34 percent / CF₃COOH; H₂O / dioxane / 20 °C

2: H₂ / Pd/C / methanol / 15001.2 Torr

With water; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1021/jo035356i