tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate

Base Information

Chemical Name:tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate
CAS No.:1188292-64-9
Molecular Formula:C₂₁H₂₉NO₅
Molecular Weight:375.465
Hs Code.:

Synonyms:tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate

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Chemical Property of tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate

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Technology Process of tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate

There total 3 articles about tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 106-96-7
propargyl bromide

: 18938-60-8
(S)-tert-butyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoate

: 1188292-64-9
tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 5h; Inert atmosphere;

Reference yield:

: 16874-12-7,87553-74-0
Tyr(tBu)

: 1188292-64-9
tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 12 h / 0 - 20 °C

2: caesium carbonate / tetrahydrofuran / 2 h / 0 - 60 °C / 1500.15 Torr / Microwave irradiation; Inert atmosphere

With caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c4ob00611a

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 1188292-64-9
tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: perchloric acid / 24 h / 0 - 20 °C

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C

3: caesium carbonate / tetrahydrofuran / 2 h / 0 - 60 °C / 1500.15 Torr / Microwave irradiation; Inert atmosphere

With perchloric acid; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c4ob00611a