C₂₂H₄₀O₃Si

Base Information

• Chemical Name: C₂₂H₄₀O₃Si
• CAS No.: 1403235-21-1
• Molecular Formula: C₂₂H₄₀O₃Si
• Molecular Weight: 380.643
• Mol file: 1403235-21-1.mol

Synonyms:C₂₂H₄₀O₃Si

Chemical Property of C₂₂H₄₀O₃Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₄₀O₃Si

There total 5 articles about C₂₂H₄₀O₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C32H47NO5Si (1403235-20-0) → C22H40O3Si (1403235-21-1)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol302309c

Reference yield:

C14H20O (1403235-36-8) → C22H40O3Si (1403235-21-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / tert-butyl alcohol; water; tetrahydrofuran / 12 h / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

2.3: 6 h / -78 - 0 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.1: sodium tetrahydroborate / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium tetrahydroborate; osmium(VIII) oxide; di-n-butylboryl trifluoromethanesulfonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 2.1: |Evans Aldol Reaction / 2.2: |Evans Aldol Reaction / 2.3: |Evans Aldol Reaction;

DOI:10.1021/ol302309c

Reference yield:

(3S)-5-(benzyloxy)-3-methylpentanal (82538-49-6) → C22H40O3Si (1403235-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

1.3: 6 h / -78 - 0 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.1: sodium tetrahydroborate / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium tetrahydroborate; di-n-butylboryl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; water; 1.1: |Evans Aldol Reaction / 1.2: |Evans Aldol Reaction / 1.3: |Evans Aldol Reaction;

DOI:10.1021/ol302309c

upstream raw materials:

C₁₄H₂₀O

(3S)-5-(benzyloxy)-3-methylpentanal

C₂₆H₃₃NO₅

C₃₂H₄₇NO₅Si

Downstream raw materials:

C₂₉H₄₆O₅SSi

C₄₁H₆₉NO₈Si

C₃₅H₅₅NO₈

C₃₀H₄₉NO₅