ethyl (S)-2-[(8S,9R,13S,14R)-3-methoxy-18-nor-11,15,17-trioxo-16-azaestra-1,3,5⁽¹⁰⁾-trien-16-yl]-3-phenylpropionate

Base Information

• Chemical Name: ethyl (S)-2-[(8S,9R,13S,14R)-3-methoxy-18-nor-11,15,17-trioxo-16-azaestra-1,3,5⁽¹⁰⁾-trien-16-yl]-3-phenylpropionate
• CAS No.: 919991-16-5
• Molecular Formula: C₂₈H₂₉NO₆
• Molecular Weight: 475.541
• Mol file: 919991-16-5.mol

Synonyms:ethyl (S)-2-[(8S,9R,13S,14R)-3-methoxy-18-nor-11,15,17-trioxo-16-azaestra-1,3,5⁽¹⁰⁾-trien-16-yl]-3-phenylpropionate

Chemical Property of ethyl (S)-2-[(8S,9R,13S,14R)-3-methoxy-18-nor-11,15,17-trioxo-16-azaestra-1,3,5⁽¹⁰⁾-trien-16-yl]-3-phenylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (S)-2-[(8S,9R,13S,14R)-3-methoxy-18-nor-11,15,17-trioxo-16-azaestra-1,3,5⁽¹⁰⁾-trien-16-yl]-3-phenylpropionate

There total 1 articles about ethyl (S)-2-[(8S,9R,13S,14R)-3-methoxy-18-nor-11,15,17-trioxo-16-azaestra-1,3,5⁽¹⁰⁾-trien-16-yl]-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

1-(α-trimethylsiloxyvinyl)-6-methoxy-3,4-dihydronaphthalene + ethyl N,N-maleoyl-L-phenylalaninate (172960-26-8) → ethyl (S)-2-[(8S,9R,13S,14R)-3-methoxy-18-nor-11,15,17-trioxo-16-azaestra-1,3,5(10)-trien-16-yl]-3-phenylpropionate (919991-16-5)

Guidance literature:

1-(α-trimethylsiloxyvinyl)-6-methoxy-3,4-dihydronaphthalene; ethyl N,N-maleoyl-L-phenylalaninate; at 60 ℃; for 6h;

With hydrogenchloride; In methanol;

DOI:10.1007/s00706-005-0406-8

Reference yield: 90.0%

ethyl (S)-2-[(8S,9R,13S,14R)-3-methoxy-18-nor-11,15,17-trioxo-16-azaestra-1,3,5(10)-trien-16-yl]-3-phenylpropionate (919991-16-5) → ethyl (S)-2-[(E/Z)-(8S,9R,13S,14R)-11-hydroxyimino-3-methoxy-18-nor-15,17-dioxo-16-azaestra-1,3,5(10)-trien-16-yl]-3-phenylpropionate

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In tetrahydrofuran; methanol; water; for 16h;

DOI:10.1007/s00706-005-0406-8

Reference yield: 80.0%

ethyl (S)-2-[(8S,9R,13S,14R)-3-methoxy-18-nor-11,15,17-trioxo-16-azaestra-1,3,5(10)-trien-16-yl]-3-phenylpropionate (919991-16-5) + N-methoxylamine hydrochloride (593-56-6) → ethyl (S)-2-[(E/Z)-(8S,9R,13S,14R)-3-methoxy-11-methoxyimino-18-nor-15,17-dioxo-16-azaestra-1,3,5(10)-trien-16-yl]-3-phenylpropionate

Guidance literature:

With hydrogenchloride; sodium acetate; In tetrahydrofuran; methanol; water; for 12h;

DOI:10.1007/s00706-005-0406-8

upstream raw materials:

ethyl N,N-maleoyl-L-phenylalaninate