Technology Process of 4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine
There total 4 articles about 4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; potassium carbonate;
In
tetrahydrofuran; water;
at 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/ejoc.201100616
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-Bromosuccinimide / acetonitrile / 0 - 20 °C
2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / tetrahydrofuran / Reflux
3: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 °C
4: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; N-Bromosuccinimide; palladium diacetate; potassium hexamethylsilazane; potassium carbonate;
In
tetrahydrofuran; water; acetonitrile;
2: Suzuki-Miyaura cross-coupling;
DOI:10.1002/ejoc.201100616
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 °C
2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; potassium hexamethylsilazane; potassium carbonate;
In
tetrahydrofuran; water;
DOI:10.1002/ejoc.201100616
