4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine

Base Information

Chemical Name:4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine
CAS No.:1323359-94-9
Molecular Formula:C₂₃H₂₆N₂O
Molecular Weight:346.472
Hs Code.:

Synonyms:4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine

Suppliers and Price of 4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine

There total 4 articles about 4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₇F₃N₂O₃S

: 426840-81-5
(E)-2-[(1-ethoxy)buta-1,3-dienyl]-5,5-dimethyl-[1,3,2]dioxaborinane

: 1323359-94-9
4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/ejoc.201100616

Reference yield:

: 61-70-1
N-methyl-2-indolinone

: 1323359-94-9
4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / acetonitrile / 0 - 20 °C

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / tetrahydrofuran / Reflux

3: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 °C

4: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; N-Bromosuccinimide; palladium diacetate; potassium hexamethylsilazane; potassium carbonate; In tetrahydrofuran; water; acetonitrile; 2: Suzuki-Miyaura cross-coupling;
DOI:10.1002/ejoc.201100616

Reference yield:

: 1323359-90-5
5-[4-(dimethylamino)phenyl]-1-methylindolin-2-one

: 1323359-94-9
4-{2-[(E)-1-ethoxybuta-1,3-dienyl]-1-methyl-1H-indol-5-yl}-N,N-dimethylbenzenamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -78 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium hexamethylsilazane; potassium carbonate; In tetrahydrofuran; water;
DOI:10.1002/ejoc.201100616