(2R,3S)-1,2-Epoxy-3-(benzyloxycarbonyl-amino)-4-phenylbutane

Base Information

• Chemical Name: (2R,3S)-1,2-Epoxy-3-(benzyloxycarbonyl-amino)-4-phenylbutane
• CAS No.: 137515-66-3
• Molecular Formula: C18H19 N O3
• Molecular Weight: 297.354
• Mol file: 137515-66-3.mol

Synonyms:Carbamicacid, (1-oxiranyl-2-phenylethyl)-, phenylmethyl ester, [R-(R*,S*)]-; Carbamicacid, [(1S)-1-(2R)-oxiranyl-2-phenylethyl]-, phenylmethyl ester (9CI)

Chemical Property of (2R,3S)-1,2-Epoxy-3-(benzyloxycarbonyl-amino)-4-phenylbutane

Chemical Property:

• PSA: 50.86000
• LogP: 3.31380

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2R,3S)-1,2-EPOXY-3-(CBZ-AMINO)-4-PHENYLBUTANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,3S)-1,2-Epoxy-3-(benzyloxycarbonyl-amino)-4-phenylbutane

There total 6 articles about (2R,3S)-1,2-Epoxy-3-(benzyloxycarbonyl-amino)-4-phenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(S)-2-(phenylmethoxycarbonyl)amino-1-phenylbut-3-ene (150767-05-8) → 2(R)-3(S)-1,2-epoxy-3-phenylmethoxycarbonylamino-4-phenylbutane (137515-66-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 4 ℃; for 48h;

Reference yield: 89.0%

→ 2(R)-3(S)-1,2-epoxy-3-phenylmethoxycarbonylamino-4-phenylbutane (137515-66-3)

Guidance literature:

Reference yield:

2(R,S)-3(S)-1-chloro-2-hydroxy-3-phenylmethoxycarbonylamino-4-phenylbutane (186463-41-2) → N-benzyloxycarbonyl-3(S)-amino-1,2(S)epoxy-4-phenylbutane (128018-44-0) + 2(R)-3(S)-1,2-epoxy-3-phenylmethoxycarbonylamino-4-phenylbutane (137515-66-3)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 3h;

DOI:10.1039/b404071f

upstream raw materials:

2(R,S)-3(S)-1-chloro-2-hydroxy-3-phenylmethoxycarbonylamino-4-phenylbutane

(S)-2-(phenylmethoxycarbonyl)amino-1-phenylbut-3-ene

(S)-benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate

(2R,2S)-(3S)-1,2-epoxy-3-phenylmethoxycarbonylamino-4-phenylbutane

Downstream raw materials:

tert-butyl 2-((2S,3S)-2-hydroxy-4-phenyl-3-{[(benzyloxy)carbonyl]amino}butyl)-2-(4-pyridin-2-ylbenzyl)hydrazinecarboxylate

tert-butyl 2-((2S,3S)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxy-4-phenylbutyl)-2-ethylhydrazinecarboxylate

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