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128018-44-0

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128018-44-0 Usage

General Description

(2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane, also known as (S,S)-3-(Cbz-amino)-1,2-epoxy-4-phenylbutane, is an organic compound with the molecular formula C17H19NO3. It is a chiral molecule, meaning it has a non-superimposable mirror image, and exists as a pair of enantiomers. (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane is often used in organic synthesis as a building block for the preparation of various pharmaceuticals and biologically active compounds. The Cbz group is a protecting group that is commonly used in organic chemistry to shield an amine group from unwanted reactions, allowing for selective transformations of other functional groups. The epoxy group is a three-membered cyclic ether that is reactive and can undergo ring-opening reactions, making it useful in the construction of complex organic molecules. Overall, (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane is an important intermediate in the synthesis of various biologically active compounds and has versatile reactivity in organic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 128018-44-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,0,1 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 128018-44:
(8*1)+(7*2)+(6*8)+(5*0)+(4*1)+(3*8)+(2*4)+(1*4)=110
110 % 10 = 0
So 128018-44-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H19NO3/c20-18(22-12-15-9-5-2-6-10-15)19-16(17-13-21-17)11-14-7-3-1-4-8-14/h1-10,16-17H,11-13H2,(H,19,20)/t16-,17?/m0/s1

128018-44-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane

1.2 Other means of identification

Product number -
Other names [(1S)-1-(2S)-oxiranyl-2-phenylethyl]-carbaMic acid phenylMethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:128018-44-0 SDS

128018-44-0Relevant articles and documents

Design, biologic evaluation, and SAR of novel pseudo-peptide incorporating benzheterocycles as HIV-1 protease inhibitors

He, Meizi,Zhang, Hang,Yao, Xiaojian,Eckart, Michael,Zuo, Elizabeth,Yang, Ming

, p. 174 - 180 (2011/03/20)

A series of novel HIV-1 protease inhibitors based on the (hydroxyethylamino)-sulfonamide isostere incorporating substituted phenyls and benzheterocycle derivatives bearing rich hydrogen bonding acceptors as P 2 ligands were synthesized. Prolonged chain linking the benzhereocycle to the carbonyl group resulted in partial loss of binding affinities. Introduction of a small alkyl substituent with appropriate size to the -CH2- of P1-P2 linkage as a side chain resulted in improved inhibitory potency, and in this study, isopropyl was the best side chain. Replacement of the isobutyl substituent at P 1′group with phenyl substituent decreased the inhibitory potency. One of the most potent inhibitor, compound 23 showing high affinity to HIV-1 protease with an IC50 value of 5 nm, also exhibited good anti-SIV activity (EC50 = 0.8 μm) with low toxicity (TC 50 > 100 μm). The flexible docking of inhibitor 23 to HIV-1 protease active site rationalized the interactions with protease.

HIV protease inhibitors

-

Page/Page column 30, (2010/02/11)

Combinatorial libraries of HIV and FIV protease inhibitors are characterized by alpha-keto amide or hydroxyethylamine core structures flanked by on one side by substituted pyrrolidines, piperidines, or azasugars and on the other side by phenylalanine, tyrosine, or substituted tyrosines. The libraries are synthesized via a one step coupling reaction. Highly efficacious drug candidates are identified by screening the libraries for binding and inhibitory activity against both HIV and FIV protease. Drug candidates displaying clinically useful activity against both HIV and FIV protease are identified as being potentially resistive against a loss of inhibitory activity due to development of resistant strains of HIV.

Retroviral protease inhibitors

-

, (2008/06/13)

N-heterocyclic moiety-containing hydroxyethylamine protease inhibitor compounds, methods for making the compounds, and intermediates useful in the method. Also, a method for inhibiting retroviral proteases and for treatment or prophylaxis of a retroviral infection.

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