5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

Base Information

• Chemical Name: 5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile
• CAS No.: 847925-02-4
• Molecular Formula: C₂₄H₁₇N₃O₄
• Molecular Weight: 411.417

Synonyms:5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

Chemical Property of 5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

Chemical Property:

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Technology Process of 5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile

There total 4 articles about 5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

cyanoacetic acid amide (107-91-5) + 2-[5-benzoyl-6-(dimethylamino)-4-oxohex-5-en-1-yl]-1H-isoindol-1,3(2H)-dione (847925-01-3) → 5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile (847925-02-4)

Guidance literature:

With magnesium ethylate; In tetrahydrofuran; at 70 ℃; for 14h;

DOI:10.1002/jhet.5570410602

Reference yield:

3-oxo-3-phenylpropionic acid (614-20-0) → 5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile (847925-02-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium ethoxide / tetrahydrofuran / 4 h

1.2: 78 percent / N,N'-carbonyldiimidazole / dimethylformamide / 5 h / 20 °C

2.1: 60 percent / tetrahydrofuran / 15 h / 20 °C

3.1: 38 percent / magnesium ethoxide / tetrahydrofuran / 14 h / 70 °C

With magnesium ethylate; In tetrahydrofuran;

DOI:10.1002/jhet.5570410602

Reference yield:

4-phthalimidobutyric acid (3130-75-4) → 5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridine-3-carbonitrile (847925-02-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium ethoxide / tetrahydrofuran / 4 h

1.2: 78 percent / N,N'-carbonyldiimidazole / dimethylformamide / 5 h / 20 °C

2.1: 60 percent / tetrahydrofuran / 15 h / 20 °C

3.1: 38 percent / magnesium ethoxide / tetrahydrofuran / 14 h / 70 °C

With magnesium ethylate; In tetrahydrofuran;

DOI:10.1002/jhet.5570410602

upstream raw materials:

cyanoacetic acid amide

2-[5-benzoyl-6-(dimethylamino)-4-oxohex-5-en-1-yl]-1H-isoindol-1,3(2H)-dione

4-phthalimidobutyric acid

3-oxo-3-phenylpropionic acid

Downstream raw materials:

2-hydroxy-5-phenyl-8,9-dihydro-7H-pyrido[3,2-c]azepin-3-carboxylic acid

3-amino-5-phenyl-1,7,8,9-tetrahydro-2H-pyrido[3,2-c]azepin-2-one

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