1-benzyl-4-(2-fluoro-benzylamino)-piperidine-4-carbonitrile

Base Information

• Chemical Name: 1-benzyl-4-(2-fluoro-benzylamino)-piperidine-4-carbonitrile
• CAS No.: 937806-08-1
• Molecular Formula: C₂₀H₂₂FN₃
• Molecular Weight: 323.413
• Mol file: 937806-08-1.mol

Synonyms:1-benzyl-4-(2-fluoro-benzylamino)-piperidine-4-carbonitrile

Chemical Property of 1-benzyl-4-(2-fluoro-benzylamino)-piperidine-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-(2-fluoro-benzylamino)-piperidine-4-carbonitrile

There total 1 articles about 1-benzyl-4-(2-fluoro-benzylamino)-piperidine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-phenylmethyl-4-piperidone (3612-20-2) + potassium cyanide (151-50-8) + 2-fluorobenzylamine (89-99-6) → 1-benzyl-4-(2-fluoro-benzylamino)-piperidine-4-carbonitrile (937806-08-1)

Guidance literature:

In methanol; water; at 0 - 20 ℃; for 21h;

DOI:10.1016/j.bmcl.2007.01.104

Reference yield:

1-benzyl-4-(2-fluoro-benzylamino)-piperidine-4-carbonitrile (937806-08-1) → 1-(2-fluoro-benzyl)-3-(3-methoxy-phenyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione (937806-10-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 8 h / 20 °C

2: AcOH / H₂O / 16 h / 55 °C

3: 100 percent / H₂; aq. HCl / Pd(OH)2/C / ethanol / 72 h / 20 °C / 2327.17 Torr

With hydrogenchloride; hydrogen; acetic acid; palladium dihydroxide; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.bmcl.2007.01.104

Reference yield:

1-benzyl-4-(2-fluoro-benzylamino)-piperidine-4-carbonitrile (937806-08-1) → 1-(2-fluoro-benzyl)-3-(3-methoxy-phenyl)-8-[4-(2-methyl-imidazol-1-yl)-benzyl]-1,3,8-triaza-spiro[4.5]decane-2,4-dione

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 8 h / 20 °C

2: AcOH / H₂O / 16 h / 55 °C

3: 100 percent / H₂; aq. HCl / Pd(OH)2/C / ethanol / 72 h / 20 °C / 2327.17 Torr

4: 30 percent / NaBH(OAc)3 / CH₂Cl₂ / 12 h / 20 °C

5: 10 percent / CuI; trans-1,2-diaminocyclohexane; Cs₂CO₃ / dioxane / 24 h / 100 °C

With hydrogenchloride; copper(l) iodide; (S,S)-1,2-diaminocyclohexane; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2007.01.104

upstream raw materials:

1-phenylmethyl-4-piperidone

potassium cyanide

2-fluorobenzylamine

Downstream raw materials:

1-(2-fluoro-benzyl)-3-(3-methoxy-phenyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione

8-benzyl-1-(2-fluoro-benzyl)-3-(3-methoxy-phenyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione

8-(4-bromo-benzyl)-1-(2-fluoro-benzyl)-3-(3-methoxy-phenyl)-1,3,8-triaza-spiro[4.5]decane-2,4-dione