1,2',6'-tris(N-benzyloxycarbonyl)-4-N-(N-benzyloxycarbonylglycyl)-5-deoxy-5-fluorosporaricin B

Base Information

Chemical Name:1,2',6'-tris(N-benzyloxycarbonyl)-4-N-(N-benzyloxycarbonylglycyl)-5-deoxy-5-fluorosporaricin B
CAS No.:86651-57-2
Molecular Formula:C₄₉H₅₈FN₅O₁₂
Molecular Weight:928.024
Hs Code.:

Synonyms:1,2',6'-tris(N-benzyloxycarbonyl)-4-N-(N-benzyloxycarbonylglycyl)-5-deoxy-5-fluorosporaricin B

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Chemical Property of 1,2',6'-tris(N-benzyloxycarbonyl)-4-N-(N-benzyloxycarbonylglycyl)-5-deoxy-5-fluorosporaricin B

Chemical Property:

Purity/Quality:

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Technology Process of 1,2',6'-tris(N-benzyloxycarbonyl)-4-N-(N-benzyloxycarbonylglycyl)-5-deoxy-5-fluorosporaricin B

There total 8 articles about 1,2',6'-tris(N-benzyloxycarbonyl)-4-N-(N-benzyloxycarbonylglycyl)-5-deoxy-5-fluorosporaricin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68743-78-2,71657-28-8,75829-53-7,81738-62-7,81768-56-1,81800-11-5,83648-64-0
sporaricin B base

: 86651-57-2
1,2',6'-tris(N-benzyloxycarbonyl)-4-N-(N-benzyloxycarbonylglycyl)-5-deoxy-5-fluorosporaricin B

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent

2: 31 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 1.) 15 min, -15 deg C; 2.) 30 min, r.t.

3: 79 percent / 0.2 M hydrochloric acid, hydrogen / 10 percent palladium-on-charcoal / methanol / 4 h / 760 Torr

4: 405 mg / methanol / 1 h / Heating

5: triethylamine / various solvent(s) / 37 °C / Heating

6: 372 mg / 0.2 M hydrochloric acid / H₂O

7: 224 mg / sodium carbonate / methanol / 1 h / Ambient temperature

With hydrogenchloride; diethylamino-sulfur trifluoride; hydrogen; sodium carbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1016/0008-6215(83)88118-X

Reference yield:

: 86651-54-9
1,4,2',6'-tetrakis(N-benzyloxycarbonyl)-5-deoxy-5-fluorosporaricin B

: 86651-57-2
1,2',6'-tris(N-benzyloxycarbonyl)-4-N-(N-benzyloxycarbonylglycyl)-5-deoxy-5-fluorosporaricin B

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / 0.2 M hydrochloric acid, hydrogen / 10 percent palladium-on-charcoal / methanol / 4 h / 760 Torr

2: 405 mg / methanol / 1 h / Heating

3: triethylamine / various solvent(s) / 37 °C / Heating

4: 372 mg / 0.2 M hydrochloric acid / H₂O

5: 224 mg / sodium carbonate / methanol / 1 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium carbonate; triethylamine; palladium on activated charcoal; In methanol; water;
DOI:10.1016/0008-6215(83)88118-X

Reference yield:

: 74556-46-0,78340-65-5
{(1S,2R,3R,4R,6S)-4-Benzyloxycarbonylamino-3-[(2R,3R,6S)-3-benzyloxycarbonylamino-6-((R)-1-benzyloxycarbonylamino-ethyl)-tetrahydro-pyran-2-yloxy]-2-hydroxy-6-methoxy-cyclohexyl}-methyl-carbamic acid benzyl ester

: 86651-57-2
1,2',6'-tris(N-benzyloxycarbonyl)-4-N-(N-benzyloxycarbonylglycyl)-5-deoxy-5-fluorosporaricin B

Guidance literature:: Multi-step reaction with 6 steps

1: 31 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 1.) 15 min, -15 deg C; 2.) 30 min, r.t.

2: 79 percent / 0.2 M hydrochloric acid, hydrogen / 10 percent palladium-on-charcoal / methanol / 4 h / 760 Torr

3: 405 mg / methanol / 1 h / Heating

4: triethylamine / various solvent(s) / 37 °C / Heating

5: 372 mg / 0.2 M hydrochloric acid / H₂O

6: 224 mg / sodium carbonate / methanol / 1 h / Ambient temperature

With hydrogenchloride; diethylamino-sulfur trifluoride; hydrogen; sodium carbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; water;
DOI:10.1016/0008-6215(83)88118-X