Technology Process of C14H16F2N2O
There total 10 articles about C14H16F2N2O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
sulfolane; water;
at 20 - 60 ℃;
pH=10;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium diacetate; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene / methanol / 16 h / 40 °C / 4137.29 Torr / Autoclave
2.1: potassium phosphate / water
2.2: 21 h / 50 - 70 °C
3.1: hydrogenchloride / sulfolane; water / 60 °C
4.1: sodium hydroxide / sulfolane; water / 20 - 60 °C / pH 10
With
hydrogenchloride; potassium phosphate; hydrogen; sodium hydroxide;
(2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; palladium diacetate;
In
sulfolane; methanol; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / 2-methyltetrahydrofuran / 75 °C / Inert atmosphere
2.1: hydrogen / palladium diacetate; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene / methanol / 16 h / 40 °C / 4137.29 Torr / Autoclave
3.1: potassium phosphate / water
3.2: 21 h / 50 - 70 °C
4.1: hydrogenchloride / sulfolane; water / 60 °C
5.1: sodium hydroxide / sulfolane; water / 20 - 60 °C / pH 10
With
hydrogenchloride; potassium phosphate; hydrogen; sodium hydroxide;
(2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; palladium diacetate; toluene-4-sulfonic acid;
In
2-methyltetrahydrofuran; sulfolane; methanol; water;