ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

Base Information

• Chemical Name: ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate
• CAS No.: 957121-89-0
• Molecular Formula: C₁₈H₂₂F₂N₂O₃
• Molecular Weight: 352.381
• Mol file: 957121-89-0.mol

Synonyms:ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

Chemical Property of ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

There total 23 articles about ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H16F2N2O (1260403-67-5) + ethyl bromoacetate (105-36-2) → ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate (957121-89-0)

Guidance literature:

C₁₄H₁₆F₂N₂O; With sodium hexamethyldisilazane; In tetrahydrofuran; at -20 - -10 ℃;

ethyl bromoacetate; In tetrahydrofuran; at -15 - -10 ℃;

Reference yield:

C15H17F2NO5S + GlyOEt*HCl (459-73-4) → ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate (957121-89-0)

Guidance literature:

C₁₅H₁₇F₂NO₅S; GlyOEt*HCl; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; Industry scale;

With acetic acid; In N,N-dimethyl-formamide; acetonitrile; at 70 ℃; Industry scale;

With sodium hydroxide; In water; N,N-dimethyl-formamide; toluene; acetonitrile; pH=8; Industry scale;

Reference yield:

methyl 1-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}cyclopentanecarboxylate trifluoroacetate (1263291-80-0) + glycine ethyl ester hydrochloride (623-33-6) → ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate (957121-89-0) + ethyl [(8S)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

Guidance literature:

methyl 1-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}cyclopentanecarboxylate trifluoroacetate; glycine ethyl ester hydrochloride; With acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; at 20 ℃; for 0.166667h;

With sodium cyanoborohydride; In methanol; at 60 ℃; for 72h;

upstream raw materials:

methyl 1-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}cyclopentanecarboxylate trifluoroacetate

glycine ethyl ester hydrochloride

3,5-difluorobromobenzene

GlyOEt*HCl

Downstream raw materials:

lithium [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

C₁₈H₁₄O₈*C₁₈H₂₂F₂N₂O₃

[3H]-MK 3207

C₁₆H₁₈F₂N₂O₃