di-tert-butyl <2-fluoro-4-benzoyl>-L-glutamate

Base Information

Chemical Name:di-tert-butyl <2-fluoro-4-benzoyl>-L-glutamate
CAS No.:157665-26-4
Molecular Formula:C₂₄H₃₇FN₂O₇
Molecular Weight:484.565
Hs Code.:

di-tert-butyl <2-fluoro-4-<bis(2-hydroxyethyl)amino>benzoyl>-L-glutamate

Synonyms:di-tert-butyl <2-fluoro-4-benzoyl>-L-glutamate

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Chemical Property of di-tert-butyl <2-fluoro-4-benzoyl>-L-glutamate

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Technology Process of di-tert-butyl <2-fluoro-4-benzoyl>-L-glutamate

There total 4 articles about di-tert-butyl <2-fluoro-4-benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 75-21-8,99932-75-9
oxirane

: 85803-27-6
di-tert-butyl N-(4-amino-2-fluorobenzoyl)-L-glutamate

: 157665-26-4
di-tert-butyl <2-fluoro-4-benzoyl>-L-glutamate

Guidance literature:: With acetic acid; for 112h; Ambient temperature;
DOI:10.1021/jm00041a015

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 157665-26-4
di-tert-butyl <2-fluoro-4-benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / SOCl₂ / toluene / 3 h / Heating

2: 94 percent / Et₃N / CH₂Cl₂

3: 96 percent / ammonium formate / 10percent Pd/C / methanol

4: 49 percent / HOAc / 112 h / Ambient temperature

With thionyl chloride; ammonium formate; acetic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; toluene;
DOI:10.1021/jm00041a015

Reference yield:

: 403-23-6
2-fluoro-4-nitrobenzoyl chloride

: 157665-26-4
di-tert-butyl <2-fluoro-4-benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / Et₃N / CH₂Cl₂

2: 96 percent / ammonium formate / 10percent Pd/C / methanol

3: 49 percent / HOAc / 112 h / Ambient temperature

With ammonium formate; acetic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00041a015