4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Base Information

• Chemical Name: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
• CAS No.: 119018-29-0
• Molecular Formula: C16H21N3O4S
• Molecular Weight: 351.426
• Hs Code.: 2935909550
• Mol file: 119018-29-0.mol

Synonyms:4-(2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl)-Benzenesulfonyl;3-ethyl-4-methyl-2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2,5-dihydro-1H-pyrrole-1-carboxamide;1H-pyrrole-1-carboxamide, N-[2-[4-(aminosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo-;

Chemical Property of 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Chemical Property:

• Appearance/Colour: white solid
• Melting Point: 177-179?C
• Refractive Index: 1.588
• PKA: 10.16±0.10(Predicted)
• PSA: 117.95000
• Density: 1.305 g/cm³
• LogP: 3.26470
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

Glimepiride Related Compound B ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 52/53:
• Hazard Codes: 52/53:
• Statements: 52/53
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate for the preparation of Glimepiride 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide (Glimepiride EP Impurity B) is an intermediate for the preparation of Glimepiride.

Technology Process of 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

There total 12 articles about 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]benzene-1-sulfonyl chloride (119043-16-2) → N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide (119018-29-0)

Guidance literature:

With ammonia; In water; at 80 ℃; for 1.5h;

Reference yield: 93.6%

C24H30N4O6S + 4-(2-aminoethyl)benzenesulfonamide (35303-76-5) → N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide (119018-29-0)

Guidance literature:

With propionic acid; In isopropyl alcohol; for 7.5h; Reagent/catalyst; Reflux;

Reference yield: 90.28%

4-{2-[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carbonyl)amino]ethyl}benzene-1-sulfonic acid → N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide (119018-29-0)

Guidance literature:

With ammonia; In 1,4-dioxane; at 35 ℃; Temperature;

upstream raw materials:

4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]benzene-1-sulfonyl chloride

3-ethyl-4-methyl-3-pyrrolin-2-one

1-acetyl-3-ethyl-4-methyl-1,5-dihydro-pyrrol-2-one

ethyl-α-ethylacetoacetate cyanohydrin

Downstream raw materials:

glimepiride

glimepiride

amaryl

C₃₂H₄₂N₄O₇S

Refernces

• 1、 -. "Preparation method of high-purity glimepiride". Paragraph 0033. . Retrieved 2020/03/29.
• 2、 -. "Process for synthesizing glimepiride raw material medicine". Paragraph 0101; 0102. . Retrieved 2018/09/08.