4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoic acid

Base Information

Chemical Name:4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoic acid
CAS No.:1334607-75-8
Molecular Formula:C₂₅H₂₇ClN₂O₄
Molecular Weight:454.953
Hs Code.:

Synonyms:4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoic acid

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Chemical Property of 4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoic acid

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Technology Process of 4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoic acid

There total 6 articles about 4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334608-21-7
ethyl 4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoate

: 1334607-75-8
4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoic acid

Guidance literature:: ethyl 4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoate; With water; sodium hydroxide; In isopropyl alcohol; at 20 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In water; pH=6;

Reference yield:

: 201849-21-0
4-bromo-2-chloro-1-[(1-methylethyl)oxy]benzene

: 1334607-75-8
4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

4.1: sodium hydroxide; water / isopropyl alcohol / 2 h / 20 °C / Inert atmosphere

4.2: pH 6

With potassium phosphate; water; potassium acetate; sodium carbonate; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1334607-75-8
4-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]oxy}butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 3 h / 80 °C / Inert atmosphere; Sealed

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

3.1: sodium hydroxide; water / isopropyl alcohol / 2 h / 20 °C / Inert atmosphere

3.2: pH 6

With potassium phosphate; water; potassium carbonate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; isopropyl alcohol; acetonitrile;