3-Choloro-4-isoproxyphenylboronic acid pinacol ester

Base Information

• Chemical Name: 3-Choloro-4-isoproxyphenylboronic acid pinacol ester
• CAS No.: 1260023-79-7
• Molecular Formula: C₁₅H₂₂BClO₃
• Molecular Weight: 296.602
• Hs Code.: 2931900090
• Mol file: 1260023-79-7.mol

Synonyms:2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 3-Choloro-4-isoproxyphenylboronic acid pinacol ester

Chemical Property:

• Boiling Point: 376.7±32.0 °C(Predicted)
• Density: 1.09±0.1 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

3-Choloro-4-isoproxyphenylboronicacidpinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Choloro-4-isoproxyphenylboronic acid pinacol ester

There total 4 articles about 3-Choloro-4-isoproxyphenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1260023-79-7)

Guidance literature:

Reference yield:

4-bromo-2-chloro-1-[(1-methylethyl)oxy]benzene (201849-21-0) + bis(pinacol)diborane (73183-34-3) → 2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1260023-79-7)

Guidance literature:

With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 20 - 80 ℃; Inert atmosphere;

Reference yield:

2-chloro-4-iodo-1-isopropoxybenzene + bis(pinacol)diborane (73183-34-3) → 2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1260023-79-7)

Guidance literature:

With potassium acetate; palladium diacetate; In N,N-dimethyl-formamide; at 90 ℃; for 5h; Inert atmosphere;

upstream raw materials:

4-bromo-2-chloro-1-[(1-methylethyl)oxy]benzene

bis(pinacol)diborane

4-bromo-2-chlorophenol

Downstream raw materials:

2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazole

5-bromo-2-(3-chloro-4-isopropoxy-phenyl)-pyrimidine

2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-[2-ethyl-3-(4-piperidinyl)phenyl]pyrimidine

ethyl 3-{4-[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]-1-piperidinyl}propanoate

Refernces

• 1、 -. "GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE". Paragraph 00609; 00610; 00612. . Retrieved 2019/07/17.
• 2、 -. "PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS". Paragraph 0161; 0162. . Retrieved 2013/03/26.