5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide

Base Information

Chemical Name:5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide
CAS No.:97059-78-4
Molecular Formula:C₁₈H₁₅FN₂O₂S
Molecular Weight:342.394
Hs Code.:

Synonyms:5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide

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Chemical Property of 5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide

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Technology Process of 5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide

There total 3 articles about 5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 97059-72-8
5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole

: 97059-78-4
5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jm00147a008

Reference yield:

: 2729-19-3
2-(4-Fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one

: 97059-78-4
5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂ / CCl₄ / 1 h / Ambient temperature

2: 30 percent / K₂CO₃ / acetonitrile / 18 h / Ambient temperature

3: 48 percent / m-CPBA / CH₂Cl₂ / 1 h / 0 °C

With bromine; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrachloromethane; dichloromethane; acetonitrile;
DOI:10.1021/jm00147a008

Reference yield:

: 951744-04-0
2-bromo-2-(4-fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one

: 97059-78-4
5-(4-Fluoro-phenyl)-6-(4-methoxy-phenyl)-2,3-dihydro-imidazo[2,1-b]thiazole 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / K₂CO₃ / acetonitrile / 18 h / Ambient temperature

2: 48 percent / m-CPBA / CH₂Cl₂ / 1 h / 0 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm00147a008