Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)-

Base Information

• Chemical Name: Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)-
• CAS No.: 2729-19-3
• Molecular Formula: C15H13FO2
• Molecular Weight: 244.265
• Mol file: 2729-19-3.mol

Synonyms:2-(4-Fluoro-phenyl)-1-(4-methoxy-phenyl)-ethanone;2-(4-fluorophenyl)-1-(4-methoxyphenyl)ethanone;(p-fluorobenzyl)(p-methoxyphenyl)ketone;4'-fluoro-4-methoxy-deoxybenzoin;4'-Fluor-4-methoxy-desoxybenzoin;

Chemical Property of Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)-

Chemical Property:

• Melting Point: 106 - 108 °C (cyclohexane)
• Boiling Point: 197-202 °C(Press: 7 Torr)
• PSA: 26.30000
• Density: 1.163±0.06 g/cm3(Predicted)
• LogP: 3.25970

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)-

There total 5 articles about Ethanone, 2-(4-fluorophenyl)-1-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methoxybenzene (100-66-3) + 4-Fluorophenylacetyl chloride (459-04-1) → 2-(4-Fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one (2729-19-3)

Guidance literature:

With aluminium trichloride; In dichloromethane; Ambient temperature;

DOI:10.1016/0223-5234(93)90031-9

Reference yield: 76.0%

methoxybenzene (100-66-3) + p-Fluorophenylacetic acid (405-50-5) → 2-(4-Fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one (2729-19-3)

Guidance literature:

methoxybenzene; p-Fluorophenylacetic acid; With tetraphosphoric acid; In acetonitrile; at 20 ℃; for 0.166667h;

With trifluoroacetic anhydride; In acetonitrile; at 20 ℃; for 8h;

DOI:10.1016/j.tet.2015.10.060

Reference yield: 59.0%

→ 2-(4-Fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one (2729-19-3)

Guidance literature:

upstream raw materials:

methoxybenzene

4-Fluorophenylacetyl chloride

p-Fluorophenylacetic acid

p-cyanophenyl methyl sulfide

Downstream raw materials:

2-(4-fluoro-phenyl)-1,1-bis-(4-methoxy-phenyl)-ethanol

1,2-bis-(4-fluoro-phenyl)-1-(4-methoxy-phenyl)-ethanol

2-bromo-2-(4-fluorophenyl)-1-(4-methoxyphenyl)ethan-1-one

2-(4-Fluoro-phenyl)-1-(4-methoxy-phenyl)-ethanol