2-((2,4-dimethoxypyrimidin-5-yl)methyl)-1-(toluene-4-sulfonyl)-1H-indole

Base Information

Chemical Name:2-((2,4-dimethoxypyrimidin-5-yl)methyl)-1-(toluene-4-sulfonyl)-1H-indole
CAS No.:1379771-58-0
Molecular Formula:C₂₂H₂₁N₃O₄S
Molecular Weight:423.492
Hs Code.:

Synonyms:2-((2,4-dimethoxypyrimidin-5-yl)methyl)-1-(toluene-4-sulfonyl)-1H-indole

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Chemical Property of 2-((2,4-dimethoxypyrimidin-5-yl)methyl)-1-(toluene-4-sulfonyl)-1H-indole

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Technology Process of 2-((2,4-dimethoxypyrimidin-5-yl)methyl)-1-(toluene-4-sulfonyl)-1H-indole

There total 9 articles about 2-((2,4-dimethoxypyrimidin-5-yl)methyl)-1-(toluene-4-sulfonyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1357000-32-8
4-methyl-N-[2-(prop-2-yn-1-yl)phenyl]benzenesulfonamide

: 52522-99-3
2,4-dimethoxy-5-iodopyrimidine

: 1379771-58-0
2-((2,4-dimethoxypyrimidin-5-yl)methyl)-1-(toluene-4-sulfonyl)-1H-indole

: 173436-68-5
2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

Guidance literature:: 2,4-dimethoxy-5-iodopyrimidine; With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

4-methyl-N-[2-(prop-2-yn-1-yl)phenyl]benzenesulfonamide; In N,N-dimethyl-formamide; at 85 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c3ob41961d

Reference yield:

: 1-(2-azidophenyl)prop-2-yn-1-ol

: 1379771-58-0
2-((2,4-dimethoxypyrimidin-5-yl)methyl)-1-(toluene-4-sulfonyl)-1H-indole

: 173436-68-5
2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: palladium diacetate; triphenylphosphine; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

4.2: 1 h / 85 °C / Inert atmosphere

With pyridine; triethylsilane; lithium aluminium tetrahydride; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ob41961d

Reference yield:

: 1207875-22-6
1-azido-2-(prop-2-ynyl)benzene

: 1379771-58-0
2-((2,4-dimethoxypyrimidin-5-yl)methyl)-1-(toluene-4-sulfonyl)-1H-indole

: 173436-68-5
2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3.1: palladium diacetate; triphenylphosphine; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

3.2: 1 h / 85 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ob41961d