Technology Process of 5-[(4-acetylphenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine
There total 4 articles about 5-[(4-acetylphenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydroxide monohydrate; mercaptoacetic acid;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1055/s-0031-1290524
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / -50 - 20 °C
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C
2.2: 0 - 20 °C
3.1: lithium hydroxide monohydrate; mercaptoacetic acid / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; lithium hydroxide monohydrate; mercaptoacetic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1055/s-0031-1290524
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C
2.2: 0 - 20 °C
3.1: lithium hydroxide monohydrate; mercaptoacetic acid / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
With
pyridine; lithium hydroxide monohydrate; mercaptoacetic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1055/s-0031-1290524