(S)-2-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-propane-1-sulfonic acid ((S)-1-cyclohexyl-ethyl)-amide

Base Information

Chemical Name:(S)-2-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-propane-1-sulfonic acid ((S)-1-cyclohexyl-ethyl)-amide
CAS No.:266351-33-1
Molecular Formula:C₂₄H₃₀Cl₂N₂O₃S
Molecular Weight:497.486
Hs Code.:

Synonyms:(S)-2-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-propane-1-sulfonic acid ((S)-1-cyclohexyl-ethyl)-amide

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Chemical Property of (S)-2-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-propane-1-sulfonic acid ((S)-1-cyclohexyl-ethyl)-amide

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Technology Process of (S)-2-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-propane-1-sulfonic acid ((S)-1-cyclohexyl-ethyl)-amide

There total 4 articles about (S)-2-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-propane-1-sulfonic acid ((S)-1-cyclohexyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-Amino-3-phenyl-propane-1-sulfonic acid ((S)-1-cyclohexyl-ethyl)-amide; compound with trifluoro-acetic acid

: 90-60-8
3,5-dichlorosalicyclaldehyde

: 266351-33-1
(S)-2-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-propane-1-sulfonic acid ((S)-1-cyclohexyl-ethyl)-amide

Guidance literature:: With polystyrene-bound 4-(N-benzyl-N-methylamino)pyridine; In methanol; at 20 ℃; for 24h;
DOI:10.1002/(SICI)1521-3773(20000303)39:5<916::AID-ANIE916>3.0.CO;2-M

Reference yield:

: 17430-98-7
[(1S)-1-cyclohexylethyl]amine

: 266351-33-1
(S)-2-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-propane-1-sulfonic acid ((S)-1-cyclohexyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: methyl trimethylsilyl dimethylketene acetal; polymer-bound 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 20 °C

2: CH₂Cl₂ / 0.5 h / 20 °C

3: polymer-bound dimethylaminopyridine / methanol / 24 h / 20 °C

With 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene; polymer-bound 4-dimethylaminopyridine; polymer-bound dimethylaminopyridine; In methanol; dichloromethane;
DOI:10.1002/1521-3765(20010618)7:12<2628::AID-CHEM26280>3.0.CO;2-7

Reference yield:

: 184916-33-4
((S)-1-Chlorosulfonylmethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester

: 266351-33-1
(S)-2-{[1-(3,5-Dichloro-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-propane-1-sulfonic acid ((S)-1-cyclohexyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: methyl trimethylsilyl dimethylketene acetal; polymer-bound 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 20 °C

2: CH₂Cl₂ / 0.5 h / 20 °C

3: polymer-bound dimethylaminopyridine / methanol / 24 h / 20 °C

With 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene; polymer-bound 4-dimethylaminopyridine; polymer-bound dimethylaminopyridine; In methanol; dichloromethane;
DOI:10.1002/1521-3765(20010618)7:12<2628::AID-CHEM26280>3.0.CO;2-7