184916-33-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 126301-32-4 (S)-2-amino-3-phenylpropane-1-sulfonic acid 

Downstream Products

• 179911-17-2 ((S)-2-tert-Butoxycarbonylamino-3-phenyl-propane-1-sulfonylamino)-acetic acid methyl ester 
• 145641-43-6 N-phenylalanine methyl ester 
• 185548-35-0 ((S)-1-Benzyl-2-benzylsulfamoyl-ethyl)-carbamic acid tert-butyl ester 
• 213740-71-7 3,5-Bis-{[2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propane-1-sulfonylamino)-ethanesulfonylamino]-methyl}-benzoic acid methyl ester 
• 503625-42-1 [(S)-1-Benzyl-2-((S)-1-phenyl-ethylsulfamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 503625-28-3 [(S)-1-Benzyl-2-((S)-1-cyclohexyl-ethylsulfamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 503625-44-3 (1-benzyl-2-isopropylsulfamoyl-ethyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

A new method for the solution and solid phase synthesis of chiral β-sulfonopeptides under mild conditions

Chiral β-sulfonopeptides were synthesized both in solution and in the solid phase using the sulfonyl chlorides derived from enantiomerically pure 2-substituted taurines under mild coupling conditions [cat. 4-dimethylaminopyridine (DMAP) and excess methyl trimethylsilyl dimethylketene acetal (MTDA) as a proton trap].

Hydrogen-bonding donor/acceptor scales in β-sulfonamidopeptides

The conformational preferences of β-sulfonamidopeptides in chloroform solution were investigated by variable-temperature 1H NMR spectroscopy and FT-IR spectroscopy. The following hydrogen-bonding acceptor scale was derived from the experiments:

Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin

Using Boc or Fmoc-protected β-substituted aminoethanesulfonyl chlorides (2-substituted taurylchlorides) the solid-phase synthesis of dipeptidosulfonamides as well as peptidosulfonamide containing peptides derived from Leu-enkephalin is described. The binding activity of the peptidosulfonamide YGGFL derivatives is reported.