(E)-N'-[1-(1H-indol-2-yl)ethylidene]-5-bromo-2-ethoxybenzohydrazide

Base Information

• Chemical Name: (E)-N'-[1-(1H-indol-2-yl)ethylidene]-5-bromo-2-ethoxybenzohydrazide
• CAS No.: 1373438-78-8
• Molecular Formula: C₁₉H₁₈BrN₃O₂
• Molecular Weight: 400.275
• Mol file: 1373438-78-8.mol

Synonyms:(E)-N'-[1-(1H-indol-2-yl)ethylidene]-5-bromo-2-ethoxybenzohydrazide

Chemical Property of (E)-N'-[1-(1H-indol-2-yl)ethylidene]-5-bromo-2-ethoxybenzohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N'-[1-(1H-indol-2-yl)ethylidene]-5-bromo-2-ethoxybenzohydrazide

There total 3 articles about (E)-N'-[1-(1H-indol-2-yl)ethylidene]-5-bromo-2-ethoxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-acetylindole (4264-35-1) + 5-Bromo-2-ethoxy-benzoic acid hydrazide (24123-35-1) → (E)-N'-[1-(1H-indol-2-yl)ethylidene]-5-bromo-2-ethoxybenzohydrazide (1373438-78-8)

Guidance literature:

With acetic acid; In ethanol; Reflux;

DOI:10.1016/j.bmc.2012.10.002

Reference yield: 84.0%

→ (E)-N'-[1-(1H-indol-2-yl)ethylidene]-5-bromo-2-ethoxybenzohydrazide (1373438-78-8)

Guidance literature:

Reference yield:

methyl 5-bromo-2-ethoxybenzoate (773873-65-7) → (E)-N'-[1-(1H-indol-2-yl)ethylidene]-5-bromo-2-ethoxybenzohydrazide (1373438-78-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 1 h / 100 °C / Microwave irradiation

2: acetic acid / ethanol / Reflux

With hydrazine hydrate; acetic acid; In ethanol;

DOI:10.1016/j.bmc.2012.10.002

upstream raw materials:

2-acetylindole

5-Bromo-2-ethoxy-benzoic acid hydrazide

methyl 5-bromo-2-ethoxybenzoate