4264-35-1

Basic information

• Product Name: 2-ACETYLINDOLE
• Synonyms: Ethanone, 1-(1H-indol-2-yl)- (9CI);1-(1H-Indole-2-yl)ethanone;2-Acetyl-1H-indole;1-(1H-indol-2-yl)ethan-1-one;Indol-2-yl Methyl Ketone;1-(Indol-2-yl)ethanone
• CAS NO: 4264-35-1
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18456
• Product Categories: ACETYLGROUP;Indole Derivatives;Intermediates
• Mol File: 4264-35-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 154-155°C
• Boiling Point: 333.9 °C at 760 mmHg
• Flash Point: 163.7 °C
• Appearance: /
• Density: 1.193 g/cm³
• Vapor Pressure: 0.000132mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: Refrigerator
• PKA: 14.79±0.30(Predicted)
• CAS DataBase Reference: 2-ACETYLINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETYLINDOLE(4264-35-1)
• EPA Substance Registry System: 2-ACETYLINDOLE(4264-35-1)

Safety Data

• Hazardous Substances Data: 4264-35-1(Hazardous Substances Data)

Usage

Chemical Properties

2-ACETYLINDOLE is Yellow Crystalline Solid

Uses

Different sources of media describe the Uses of 4264-35-1 differently. You can refer to the following data:
1. 2-ACETYLINDOLE is a useful intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals
2. An indole derivative used in synthesis of matrix metalloprotease inhibitors.

InChI:InChI=1/C10H9NO/c1-7(12)10-6-8-4-2-3-5-9(8)11-10/h2-6,11H,1H3

Upstream product

• 1137-96-8 (Z)-N-benzylideneaniline oxide 
• 1423-60-5 methyl ethynyl ketone 
• 120-72-9 indole 
• 108-24-7 acetic anhydride 
• 1255952-14-7 4-(2-azido-phenyl)-but-3-en-2-one 
• 552-89-6 2-nitro-benzaldehyde 
• 16714-25-3 2-azidobenzaldehyde 
• 67-56-1 methanol 
• 1435944-00-5 N-(2-(3-oxobutyl)phenyl)-4-methylbenzenesulfonamide 
• 101315-51-9 2-(Pyruvoylamino)benzyltriphenylphosphoniumbromid 

Downstream Products

• 95306-87-9 1-(1-benzyl-1H-indol-2-yl)ethan-1-one 
• 1313534-76-7 tert-butyl 3-((tert-butyldimethylsilyloxy)methyl)-1-methyl-4-phenyl-9H-pyrido[3,4-b]indole-9-carboxylate 
• 1313534-55-2 tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-1-methyl-3-phenyl-9H-pyrido[3,4-b]indole-9-carboxylate 
• 1313534-56-3 9-tert-butyl 4-methyl 1-methyl-3-phenyl-9H-pyrido[3,4-b]indole-4,9-dicarboxylate 
• 1313534-78-9 9-tert-butyl 3-methyl 1-methyl-4-phenyl-9H-pyrido[3,4-b]indole-3,9-dicarboxylate 
• 1313534-45-0 tert-butyl 1-methyl-3,4-diphenyl-9H-pyrido[3,4-b]indole-9-carboxylate 
• 1313535-06-6 tert-butyl (E)-2-(1-(hydroxyimino)ethyl)-1H-indole-1-carboxylate 
• 1313534-47-2 tert-butyl 3,4-bis(4-methoxyphenyl)-1-methyl-9H-pyrido[3,4-b]indole-9-carboxylate 
• 1313534-49-4 tert-butyl 3,4-bis(4-bromophenyl)-1-methyl-9H-pyrido[3,4-b]indole-9-carboxylate 
• 1313534-73-4 tert-butyl 1,3-dimethyl-4-phenyl-9H-pyrido[3,4-b]indole-9-carboxylate 
• 1313534-53-0 tert-butyl 1,4-dimethyl-3-phenyl-9H-pyrido[3,4-b]indole-9-carboxylate 

Relevant articles and documents

Imidazolium Triflate Ionic Liquid Improves the Activity of ZnCl2 in the Synthesis of Pyrroles and Ketones

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Iodine-mediated intramolecular amination of ketones: The synthesis of 2-acylindoles and 2-acylindolines by tuning N-protecting groups

A general method for constructing both 2-acylindoles and 2-acylindolines via I2-mediated intramolecular C-N bond formation is presented, and the selective formation of either 2-acylindoles or 2-acylindolines just depends on the nitrogen protecting groups used in the same substrate skeletons. The Royal Society of Chemistry.

THE FORMATION OF SUBSTITUTED INDOLES BY ACID CATALYZED REARRANGEMENTS OF 4-ISOXAZOLINES

Thermal rearrangements of 4-isoxazolines from C,N-diphenylnitrone and substituted alkynes have been directed towards the formation of substituted indoles.Detection and isolation of the intermediates of the process elucidate the reaction pathway.The appropriate choice of substituents and experimental conditions has allowed the control of the single steps involved in the total process.