Technology Process of 6-amino-5-bromo-2-(4-cyanophenyl)-N-methylbenzofuran-3-carboxamide
There total 7 articles about 6-amino-5-bromo-2-(4-cyanophenyl)-N-methylbenzofuran-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate;
In
1,4-dioxane; water;
at 80 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: iron; ammonium chloride / methanol; tetrahydrofuran; water / 3 h / Reflux
2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 2 h / Reflux
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 25 °C
3.2: 2 h
4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
4.2: 1 h / -78 °C
5.1: potassium phosphate tribasic trihydrate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 4 h / 80 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; potassium phosphate tribasic trihydrate; water; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
5.1: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 2 h / Reflux
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 25 °C
2.2: 2 h
3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 °C
4.1: potassium phosphate tribasic trihydrate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 4 h / 80 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; potassium phosphate tribasic trihydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
4.1: |Suzuki Coupling;
