1,1'-{ethane-1,2-diylbis[oxyethane-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy(3-methoxy-4,1-phenylene)methylene]}bis[4-(2-methoxyphenyl)piperazine]

Base Information

Chemical Name:1,1'-{ethane-1,2-diylbis[oxyethane-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy(3-methoxy-4,1-phenylene)methylene]}bis[4-(2-methoxyphenyl)piperazine]
CAS No.:1311157-49-9
Molecular Formula:C₅₄H₇₂N₁₀O₈
Molecular Weight:989.228
Hs Code.:

1,1'-{ethane-1,2-diylbis[oxyethane-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy(3-methoxy-4,1-phenylene)methylene]}bis[4-(2-methoxyphenyl)piperazine]

Synonyms:1,1'-{ethane-1,2-diylbis[oxyethane-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy(3-methoxy-4,1-phenylene)methylene]}bis[4-(2-methoxyphenyl)piperazine]

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Chemical Property of 1,1'-{ethane-1,2-diylbis[oxyethane-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy(3-methoxy-4,1-phenylene)methylene]}bis[4-(2-methoxyphenyl)piperazine]

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Technology Process of 1,1'-{ethane-1,2-diylbis[oxyethane-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy(3-methoxy-4,1-phenylene)methylene]}bis[4-(2-methoxyphenyl)piperazine]

There total 5 articles about 1,1'-{ethane-1,2-diylbis[oxyethane-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy(3-methoxy-4,1-phenylene)methylene]}bis[4-(2-methoxyphenyl)piperazine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 1311157-56-8
4,4'-[ethane-1,2-diylbis(oxyethan-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy)]bis(3-methoxybenzaldehyde)

: 1311157-49-9
1,1'-{ethane-1,2-diylbis[oxyethane-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy(3-methoxy-4,1-phenylene)methylene]}bis[4-(2-methoxyphenyl)piperazine]

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm2004859

Reference yield:

: 19249-03-7
triethylene glycol di-(p-toluenesulfonate)

: 1311157-49-9
1,1'-{ethane-1,2-diylbis[oxyethane-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy(3-methoxy-4,1-phenylene)methylene]}bis[4-(2-methoxyphenyl)piperazine]

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 80 °C

2: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / hexane; dichloromethane; water; tert-butyl alcohol / 16 h / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 20 °C / Inert atmosphere

With sodium azide; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; sodium tris(acetoxy)borohydride; In hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm2004859

Reference yield:

: 14267-92-6
1-chloro-4-pentyne

: 1311157-49-9
1,1'-{ethane-1,2-diylbis[oxyethane-2,1-diyl-1H-1,2,3-triazole-1,4-diylpropane-3,1-diyloxy(3-methoxy-4,1-phenylene)methylene]}bis[4-(2-methoxyphenyl)piperazine]

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / acetonitrile / 16 h / Reflux

2: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / hexane; dichloromethane; water; tert-butyl alcohol / 16 h / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 20 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; sodium tris(acetoxy)borohydride; potassium carbonate; potassium iodide; In hexane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm2004859