ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate

Base Information

Chemical Name:ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate
CAS No.:1000602-42-5
Molecular Formula:C₂₄H₂₈N₂O₄
Molecular Weight:408.497
Hs Code.:

Synonyms:ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate

Suppliers and Price of ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate

There total 9 articles about ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1000605-82-2
ethyl N-[1-(3-isopropyl-4-triisopropylsilanyloxybenzyl)-7-methyl-1H-indol-4-yl]malonamate

: 1000602-42-5
ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2013.11.001

Reference yield:

: 26307-50-6
4-bromo-2-isopropyl-phenol

: 1000602-42-5
ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C

2.2: 4 h / -78 - 20 °C

3.1: thionyl chloride / dichloromethane / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C

4.2: 3 h / 5 °C

5.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C

6.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With 1H-imidazole; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil; pentane;
DOI:10.1016/j.bmc.2013.11.001

Reference yield:

: 88-69-7
2-(1-methylethyl)phenol

: 1000602-42-5
ethyl N-[1-(4-hydroxy-3-isopropylbenzyl)-7-methyl-1H-indol-4-yl]malonamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / acetonitrile / 4 h / 0 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C

3.2: 4 h / -78 - 20 °C

4.1: thionyl chloride / dichloromethane / 2 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 5 °C

5.2: 3 h / 5 °C

6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 3 h / 20 °C

7.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With 1H-imidazole; N-Bromosuccinimide; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; pentane;
DOI:10.1016/j.bmc.2013.11.001