((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate

Base Information

Chemical Name:((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate
CAS No.:322468-25-7
Molecular Formula:C₁₃H₂₀BrO₆P
Molecular Weight:383.176
Hs Code.:

Synonyms:((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate

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Chemical Property of ((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate

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Technology Process of ((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate

There total 8 articles about ((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 322468-21-3
((R)-2-O-benzyl-3-O-tritylglyceryl)-2-bromoethyl-methyl phosphate

: 322468-25-7
((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate

Guidance literature:: With ethanol; pyridine hydrochloride; for 2h; Heating;
DOI:10.1016/S0009-3084(00)00167-5

Reference yield:

: 17618-04-1
2,5-di-O-benzyl-D-mannitol

: 322468-25-7
((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / DMAP; Et₃N / CH₂Cl₂ / 6 h / 20 °C

2: 95 percent / aq. NaIO₄ / tetrahydrofuran / 2 h

3: 92 percent / NaBH₄ / methanol / 4 h / 20 °C

4: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

5: tetrahydrofuran / 2 h / -78 - 20 °C

6: 30 aq. H₂O₂ / CH₂Cl₂ / 2 h

7: 87 percent / pyridinium chloride; EtOH / 2 h / Heating

With dmap; sodium tetrahydroborate; sodium periodate; ethanol; dihydrogen peroxide; pyridine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0009-3084(00)00167-5

Reference yield:

: 90126-86-6
2,5-di-O-benzyl-1,6-di-O-trityl-D-mannitol

: 322468-25-7
((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / aq. NaIO₄ / tetrahydrofuran / 2 h

2: 92 percent / NaBH₄ / methanol / 4 h / 20 °C

3: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

4: tetrahydrofuran / 2 h / -78 - 20 °C

5: 30 aq. H₂O₂ / CH₂Cl₂ / 2 h

6: 87 percent / pyridinium chloride; EtOH / 2 h / Heating

With sodium tetrahydroborate; sodium periodate; ethanol; dihydrogen peroxide; pyridine hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0009-3084(00)00167-5