(3-O-[2-propyl pentanoyl]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Base Information

Chemical Name:(3-O-[2-propyl pentanoyl]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate
CAS No.:322468-34-8
Molecular Formula:C₂₁H₃₄BrO₇P
Molecular Weight:509.375
Hs Code.:

Synonyms:(3-O-[2-propyl pentanoyl]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

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Chemical Property of (3-O-[2-propyl pentanoyl]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Chemical Property:

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Technology Process of (3-O-[2-propyl pentanoyl]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

There total 9 articles about (3-O-[2-propyl pentanoyl]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 99-66-1
valproic acid

: 322468-25-7
((R)-2-O-benzyl-glyceryl)-2-bromoethyl-methylphosphate

: 322468-34-8
(3-O-[2-propyl pentanoyl]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 2h;
DOI:10.1016/S0009-3084(00)00167-5

Reference yield:

: 17618-04-1
2,5-di-O-benzyl-D-mannitol

: 322468-34-8
(3-O-[2-propyl pentanoyl]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / DMAP; Et₃N / CH₂Cl₂ / 6 h / 20 °C

2: 95 percent / aq. NaIO₄ / tetrahydrofuran / 2 h

3: 92 percent / NaBH₄ / methanol / 4 h / 20 °C

4: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

5: tetrahydrofuran / 2 h / -78 - 20 °C

6: 30 aq. H₂O₂ / CH₂Cl₂ / 2 h

7: 87 percent / pyridinium chloride; EtOH / 2 h / Heating

8: 92 percent / DCC; DMAP / CH₂Cl₂ / 2 h

With dmap; sodium tetrahydroborate; sodium periodate; ethanol; dihydrogen peroxide; pyridine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0009-3084(00)00167-5

Reference yield:

: 114978-02-8
2,5-di-O-benzyl-1,3(R):4,6(R)-di-O-benzylidene-D-mannitol

: 322468-34-8
(3-O-[2-propyl pentanoyl]-(R)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / aq. HCl / ethanol / 4 h / Heating

2: 98 percent / DMAP; Et₃N / CH₂Cl₂ / 6 h / 20 °C

3: 95 percent / aq. NaIO₄ / tetrahydrofuran / 2 h

4: 92 percent / NaBH₄ / methanol / 4 h / 20 °C

5: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

6: tetrahydrofuran / 2 h / -78 - 20 °C

7: 30 aq. H₂O₂ / CH₂Cl₂ / 2 h

8: 87 percent / pyridinium chloride; EtOH / 2 h / Heating

9: 92 percent / DCC; DMAP / CH₂Cl₂ / 2 h

With hydrogenchloride; dmap; sodium tetrahydroborate; sodium periodate; ethanol; dihydrogen peroxide; pyridine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/S0009-3084(00)00167-5