2-{(1R,2R,5R,6S)-2-allyl-6-[(1R,2R)-2-hydroxy-1,2-diphenylethoxy]-3-oxo-5-(pent-4-en-1-yl)cyclohexyl}acetaldehyde

Base Information

Chemical Name:2-{(1R,2R,5R,6S)-2-allyl-6-[(1R,2R)-2-hydroxy-1,2-diphenylethoxy]-3-oxo-5-(pent-4-en-1-yl)cyclohexyl}acetaldehyde
CAS No.:1429924-72-0
Molecular Formula:C₃₀H₃₆O₄
Molecular Weight:460.613
Hs Code.:

Synonyms:2-{(1R,2R,5R,6S)-2-allyl-6-[(1R,2R)-2-hydroxy-1,2-diphenylethoxy]-3-oxo-5-(pent-4-en-1-yl)cyclohexyl}acetaldehyde

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Chemical Property of 2-{(1R,2R,5R,6S)-2-allyl-6-[(1R,2R)-2-hydroxy-1,2-diphenylethoxy]-3-oxo-5-(pent-4-en-1-yl)cyclohexyl}acetaldehyde

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Technology Process of 2-{(1R,2R,5R,6S)-2-allyl-6-[(1R,2R)-2-hydroxy-1,2-diphenylethoxy]-3-oxo-5-(pent-4-en-1-yl)cyclohexyl}acetaldehyde

There total 3 articles about 2-{(1R,2R,5R,6S)-2-allyl-6-[(1R,2R)-2-hydroxy-1,2-diphenylethoxy]-3-oxo-5-(pent-4-en-1-yl)cyclohexyl}acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1429924-71-9
(1S,3R,4R,6R,8R,9R,12R)-9-allyl-6-methoxy-12-(pent-4-en-1-yl)-3,4-diphenyl-2,5-dioxabicyclo[6.4.0]dodecan-10-one

: 1429924-72-0
2-{(1R,2R,5R,6S)-2-allyl-6-[(1R,2R)-2-hydroxy-1,2-diphenylethoxy]-3-oxo-5-(pent-4-en-1-yl)cyclohexyl}acetaldehyde

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In water; acetonitrile; at 20 ℃; for 4h;
DOI:10.1002/chem.201200376

Reference yield:

: 1429924-66-2
(1S,3R,4R,6R,8R,9R)-9-allyl-6-methoxy-3,4-diphenyl-2,5-dioxabicyclo[6.4.0]dodec-11-en-10-one

: 1429924-72-0
2-{(1R,2R,5R,6S)-2-allyl-6-[(1R,2R)-2-hydroxy-1,2-diphenylethoxy]-3-oxo-5-(pent-4-en-1-yl)cyclohexyl}acetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / acetonitrile; water / 4 h / 20 °C

With copper(l) iodide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; water; acetonitrile; 1: |Michael Addition;
DOI:10.1002/chem.201200376

Reference yield:

: 1002094-23-6
(1R,3R,4R,6R,8R)-6-methoxy-3,4-diphenyl-2,5-dioxabicyclo[6.4.0]dodec-11-en-10-one

: 1429924-72-0
2-{(1R,2R,5R,6S)-2-allyl-6-[(1R,2R)-2-hydroxy-1,2-diphenylethoxy]-3-oxo-5-(pent-4-en-1-yl)cyclohexyl}acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

2.1: copper(l) iodide / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / acetonitrile; water / 4 h / 20 °C

With copper(l) iodide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane; In tetrahydrofuran; water; acetonitrile; 2.1: |Michael Addition;
DOI:10.1002/chem.201200376