Technology Process of 1-isopropylamino-3-[4-[3-(1-pyrazolyl)propyl]phenoxy]-2-propanol
There total 6 articles about 1-isopropylamino-3-[4-[3-(1-pyrazolyl)propyl]phenoxy]-2-propanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / butan-1-ol / 15 h / Heating
2: 98 percent / sodium borohydride / ethanol / 2 h
3: concd HCl, H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
4: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
5: ethanol / 18 h / Ambient temperature
With
hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydride;
palladium on activated charcoal;
In
ethanol; butan-1-ol;
DOI:10.1021/jm00370a012
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / sodium borohydride / ethanol / 2 h
2: concd HCl, H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
3: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
4: ethanol / 18 h / Ambient temperature
With
hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydride;
palladium on activated charcoal;
In
ethanol;
DOI:10.1021/jm00370a012
- Guidance literature:
-
Multi-step reaction with 3 steps
1: concd HCl, H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
2: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
3: ethanol / 18 h / Ambient temperature
With
hydrogenchloride; hydrogen; sodium hydride;
palladium on activated charcoal;
In
ethanol;
DOI:10.1021/jm00370a012