methyl N-(N-tert-butoxycarbonyl-L-seryl)-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-carboxylbenzyl]-L-cysteinate

Base Information

Chemical Name:methyl N-(N-tert-butoxycarbonyl-L-seryl)-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-carboxylbenzyl]-L-cysteinate
CAS No.:676347-05-0
Molecular Formula:C₃₂H₅₆N₂O₁₀SSi₂
Molecular Weight:717.041
Hs Code.:

Synonyms:methyl N-(N-tert-butoxycarbonyl-L-seryl)-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-carboxylbenzyl]-L-cysteinate

Suppliers and Price of methyl N-(N-tert-butoxycarbonyl-L-seryl)-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-carboxylbenzyl]-L-cysteinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl N-(N-tert-butoxycarbonyl-L-seryl)-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-carboxylbenzyl]-L-cysteinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl N-(N-tert-butoxycarbonyl-L-seryl)-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-carboxylbenzyl]-L-cysteinate

There total 6 articles about methyl N-(N-tert-butoxycarbonyl-L-seryl)-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-carboxylbenzyl]-L-cysteinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 147214-71-9
methyl N-[N-tert-butoxycarbonyl-L-seryl]-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-(4-nitrobenzyloxycarbonyl)benzyl]-L-cysteinate

: 676347-05-0
methyl N-(N-tert-butoxycarbonyl-L-seryl)-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-carboxylbenzyl]-L-cysteinate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 18h;
DOI:10.1021/jm0310232

Reference yield:

: 4780-63-6
3,5-dihydroxy-2-methylbenzoic acid

: 676347-05-0
methyl N-(N-tert-butoxycarbonyl-L-seryl)-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-carboxylbenzyl]-L-cysteinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N,N',N'-tetramethylguanidine / dimethylformamide / 0.5 h / 20 °C

1.2: 78 percent / dimethylformamide / 72 h / 20 °C

2.1: 60 percent / Et₃N / dimethylformamide / 6 h / 0 °C

3.1: 94 percent / NBS / CCl₄ / 0.67 h / Heating; irradiation

4.1: 66 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

5.1: 90 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C

With N-Bromosuccinimide; hydrogen; triethylamine; N,N,N',N'-tetramethylguanidine; palladium on activated charcoal; In tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0310232

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 676347-05-0
methyl N-(N-tert-butoxycarbonyl-L-seryl)-S-[2,4-bis[(tert-butyl)dimethylsilyloxy]-6-carboxylbenzyl]-L-cysteinate

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / Et₃N / dimethylformamide / 6 h / 0 °C

2: 94 percent / NBS / CCl₄ / 0.67 h / Heating; irradiation

3: 66 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

4: 90 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C

With N-Bromosuccinimide; hydrogen; triethylamine; palladium on activated charcoal; In tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0310232