2-(4-Fluorophenyl)pyrrolidine

Base Information

Chemical Name:2-(4-Fluorophenyl)pyrrolidine
CAS No.:72216-06-9
Molecular Formula:C10H12FN
Molecular Weight:165.21
Hs Code.:2933990090
European Community (EC) Number:675-432-1
DSSTox Substance ID:DTXSID40397587
Nikkaji Number:J2.179.799E
Mol file:72216-06-9.mol

Synonyms:2-(4-Fluorophenyl)pyrrolidine;72216-06-9;2-(4-Fluorophenyl)-pyrrolidine;2-(4-fluoro-phenyl)-pyrrolidine;PYRROLIDINE, 2-(4-FLUOROPHENYL)-;MFCD02663411;Oprea1_475262;SCHEMBL169111;DTXSID40397587;AC-450;AR1040;BBL022424;STK352016;AKOS000200861;AKOS016341057;AB12040;PS-6897;(RS)-2-(4-fluoro-phenyl)-pyrrolidine;AM804282;2-(4-fluorophenyl)pyrrolidine, AldrichCPR;BB 0219906;CS-0001894;FT-0601695;FT-0656204;FT-0659814;EN300-26301;A26406;A820082;J-505995;Z221586518

Suppliers and Price of 2-(4-Fluorophenyl)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(4-Fluorophenyl)pyrrolidine
1g
$ 75.00

SynQuest Laboratories
2-(4-Fluorophenyl)pyrrolidine 97%
250 mg
$ 32.00

SynQuest Laboratories
2-(4-Fluorophenyl)pyrrolidine 97%
1 g
$ 72.00

J&W Pharmlab
2-(4-Fluoro-phenyl)-pyrrolidine 98%
1g
$ 198.00

J&W Pharmlab
2-(4-Fluoro-phenyl)-pyrrolidine 98%
5g
$ 398.00

Chemenu
2-(4-Fluorophenyl)pyrrolidine 95%
10g
$ 340.00

Chemenu
2-(4-Fluorophenyl)pyrrolidine 95%
25g
$ 711.00

ChemBridge Corporation
2-(4-fluorophenyl)pyrrolidine 95%
250 mg
$ 170.00

Apolloscientific
2-(4-Fluorophenyl)pyrrolidine 97%
1g
$ 45.00

Apolloscientific
2-(4-Fluorophenyl)pyrrolidine 97%
250mg
$ 20.00

Total 50 raw suppliers

Chemical Property of 2-(4-Fluorophenyl)pyrrolidine

Chemical Property:

Vapor Pressure:0.0497mmHg at 25°C
Refractive Index:1.515
Boiling Point:235.5 °C at 760 mmHg
PKA:9.76±0.10(Predicted)
Flash Point:96.3 °C
PSA：12.03000
Density:1.078 g/cm³
LogP:2.57900
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:165.095377549
Heavy Atom Count:12
Complexity:141

Purity/Quality:

99%, ^*data from raw suppliers

2-(4-Fluorophenyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1)C2=CC=C(C=C2)F

Technology Process of 2-(4-Fluorophenyl)pyrrolidine

There total 9 articles about 2-(4-Fluorophenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 123-75-1
pyrrolidine

: 1493-23-8
(4-fluorophenyl)lithium

: 72216-06-9
2-(4-fluorophenyl)pyrrolidine

Guidance literature:: pyrrolidine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.166667h;

With benzophenone; In diethyl ether; hexane; at -78 ℃; for 0.166667h;

(4-fluorophenyl)lithium; In diethyl ether; hexane; at -78 - 20 ℃; regioselective reaction;
DOI:10.1038/NCHEM.2871

Reference yield:

: 22217-86-3
2-(4-fluorophenyl)-Δ¹-pyrrolidine

: 72216-06-9
2-(4-fluorophenyl)pyrrolidine

Guidance literature:: With sodium tetrahydroborate; In ethanol;
DOI:10.1016/j.bmcl.2009.12.085

Reference yield:

: 1-[2-(4-fluorophenyl)-1-pyrrolidinyl]- 2,2,2-trifluoro-ethanone

: 72216-06-9
2-(4-fluorophenyl)pyrrolidine

Guidance literature:: With potassium hydroxide; In methanol; at 0 - 20 ℃; for 12.1667h; Sealed tube; Inert atmosphere;
DOI:10.1016/j.chempr.2020.02.002