1-{[3-bromo-4-[N-(3-methoxycarbonyl-2-propenyl)trifluoroacetamido]phenyl]methylsulfonyl}pyrrolodine

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Chemical Name:1-{[3-bromo-4-[N-(3-methoxycarbonyl-2-propenyl)trifluoroacetamido]phenyl]methylsulfonyl}pyrrolodine
CAS No.:334981-24-7
Molecular Formula:C₁₈H₂₀BrF₃N₂O₅S
Molecular Weight:513.332
Hs Code.:

Synonyms:1-{[3-bromo-4-[N-(3-methoxycarbonyl-2-propenyl)trifluoroacetamido]phenyl]methylsulfonyl}pyrrolodine

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Chemical Property of 1-{[3-bromo-4-[N-(3-methoxycarbonyl-2-propenyl)trifluoroacetamido]phenyl]methylsulfonyl}pyrrolodine

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Technology Process of 1-{[3-bromo-4-[N-(3-methoxycarbonyl-2-propenyl)trifluoroacetamido]phenyl]methylsulfonyl}pyrrolodine

There total 2 articles about 1-{[3-bromo-4-[N-(3-methoxycarbonyl-2-propenyl)trifluoroacetamido]phenyl]methylsulfonyl}pyrrolodine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1117-71-1
methyl 4-bromocrotonate

: 334981-23-6
1-{[3-bromo-4-(trifluoroacetamido)phenyl]methylsulfonyl}pyrrolidine

: 334981-24-7
1-{[3-bromo-4-[N-(3-methoxycarbonyl-2-propenyl)trifluoroacetamido]phenyl]methylsulfonyl}pyrrolodine

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; for 20h; Heating;
DOI:10.1016/S0040-4020(00)01091-7

Reference yield:

: 334981-10-1
4-((pyrrolidin-1-ylsulfonyl)methyl)aniline

: 334981-24-7
1-{[3-bromo-4-[N-(3-methoxycarbonyl-2-propenyl)trifluoroacetamido]phenyl]methylsulfonyl}pyrrolodine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Br₂ / methanol / 1 h / 20 °C

1.2: 26 percent / tetrahydrofuran / 0.5 h / 20 °C

2.1: 73 percent / LDA / cyclohexane; tetrahydrofuran / 20 h / Heating

With bromine; lithium diisopropyl amide; In tetrahydrofuran; methanol; cyclohexane;
DOI:10.1016/S0040-4020(00)01091-7