5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamoyl-[3'(N)->5'(O)]-thymidine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamoyl-[3'(N)->5'(O)]-thymidine
CAS No.:428506-23-4
Molecular Formula:C₄₁H₄₅N₅O₁₃S
Molecular Weight:847.9
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamoyl-[3'(N)->5'(O)]-thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamoyl-[3'(N)->5'(O)]-thymidine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamoyl-[3'(N)->5'(O)]-thymidine

There total 6 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamoyl-[3'(N)->5'(O)]-thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 288391-05-9
5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamoyl-[3'(N)->5'(O)]-3'-O-(tert-butyldimethylsilyl)thymidine

: 428506-23-4
5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamoyl-[3'(N)->5'(O)]-thymidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 5h;
DOI:10.1039/b110603c

Reference yield:

: 919367-37-6
acetic acid 2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]sulfamoyloxymethyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 428506-23-4
5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamoyl-[3'(N)->5'(O)]-thymidine

Guidance literature:: With triethylamine; In methanol; water; at 20 - 50 ℃; for 24h;
DOI:10.1021/jo061488a

Reference yield:

: 288391-04-8
4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate

: 428506-23-4
5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamoyl-[3'(N)->5'(O)]-thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / 4 Angstroem molecular sieves; Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: 94 percent / TBAF / tetrahydrofuran / 5 h

With 4 A molecular sieve; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b110603c