(1s,4s)-4-(4-(3-(tert-butoxycarbonyl((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylamino)cyclohexyl methanesulfonate

Base Information

Chemical Name:(1s,4s)-4-(4-(3-(tert-butoxycarbonyl((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylamino)cyclohexyl methanesulfonate
CAS No.:1377698-71-9
Molecular Formula:C₂₉H₄₀ClN₃O₆S
Molecular Weight:594.172
Hs Code.:

Synonyms:(1s,4s)-4-(4-(3-(tert-butoxycarbonyl((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylamino)cyclohexyl methanesulfonate

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Chemical Property of (1s,4s)-4-(4-(3-(tert-butoxycarbonyl((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylamino)cyclohexyl methanesulfonate

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Technology Process of (1s,4s)-4-(4-(3-(tert-butoxycarbonyl((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylamino)cyclohexyl methanesulfonate

There total 5 articles about (1s,4s)-4-(4-(3-(tert-butoxycarbonyl((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylamino)cyclohexyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 659731-48-3
5-chloro-2-fluoro-4-iodopyridine

: 1377698-71-9
(1s,4s)-4-(4-(3-(tert-butoxycarbonyl((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylamino)cyclohexyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 2 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C

2.2: 40 h / 20 - 40 °C

3.1: triethylamine / dimethyl sulfoxide / 40 h / 95 - 100 °C

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With sodium hydride; sodium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1377698-66-2
tert-butyl 3-(5-chloro-2-((1s,4s)-4-hydroxycyclohexylamino)pyridin-4-yl)phenyl((tetrahydro-2H-pyran-4-yl)methyl)carbamate

: 124-63-0
methanesulfonyl chloride

: 1377698-71-9
(1s,4s)-4-(4-(3-(tert-butoxycarbonyl((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylamino)cyclohexyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 380430-68-2
3-(tert-butoxycarbonylamino)phenylboronic acid

: 1377698-71-9
(1s,4s)-4-(4-(3-(tert-butoxycarbonyl((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)-5-chloropyridin-2-ylamino)cyclohexyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 2 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 20 °C

2.2: 40 h / 20 - 40 °C

3.1: triethylamine / dimethyl sulfoxide / 40 h / 95 - 100 °C

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With sodium hydride; sodium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;