(S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetamide

Base Information

Chemical Name:(S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetamide
CAS No.:1609284-51-6
Molecular Formula:C₂₃H₁₈F₂N₂O₃
Molecular Weight:408.404
Hs Code.:

Synonyms:(S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetamide

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Chemical Property of (S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetamide

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Technology Process of (S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetamide

There total 5 articles about (S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1609284-94-7
(S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetic acid

: 1609284-51-6
(S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetamide

Guidance literature:: (S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

With ammonium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1609284-93-6
(S)-ethyl 2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetate

: 1609284-51-6
(S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 0.25 h

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 60 °C

2.2: 2 h / 20 °C

With water; 1,1'-carbonyldiimidazole; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1609284-92-5
(S)-5,5-bis(4-fluorophenyl)-4-phenyloxazolidin-2-one

: 1609284-51-6
(S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

2.1: sodium hydroxide; water / ethanol / 0.25 h

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 60 °C

3.2: 2 h / 20 °C

With water; sodium hydride; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;