(S)-ethyl 2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetate

Base Information

Chemical Name:(S)-ethyl 2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetate
CAS No.:1609284-93-6
Molecular Formula:C₂₅H₂₁F₂NO₄
Molecular Weight:437.443
Hs Code.:

Synonyms:(S)-ethyl 2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetate

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Chemical Property of (S)-ethyl 2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetate

Chemical Property:

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Technology Process of (S)-ethyl 2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetate

There total 3 articles about (S)-ethyl 2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1609284-92-5
(S)-5,5-bis(4-fluorophenyl)-4-phenyloxazolidin-2-one

: 105-36-2
ethyl bromoacetate

: 1609284-93-6
(S)-ethyl 2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetate

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; Cooling with ice;

Reference yield:

: 1609284-91-4
(S)-2-amino-1,1-bis(4-fluorophenyl)-2-phenylethanol

: 1609284-93-6
(S)-ethyl 2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C / Cooling with ice

2: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1609284-93-6
(S)-ethyl 2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazolidin-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 20 °C / Cooling with ice

2: triethylamine / dichloromethane / 20 °C / Cooling with ice

3: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;