3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

Base Information

Chemical Name:3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrol-2(5H)-one
CAS No.:1574538-43-4
Molecular Formula:C₂₆H₃₀N₂O₄
Molecular Weight:434.535
Hs Code.:

Synonyms:3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Chemical Property of 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Technology Process of 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

There total 7 articles about 3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 123-75-1
pyrrolidine

: 1574541-85-7
2-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)ethyl methanesulfonate

: 1574538-43-4
3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: With sodium carbonate; In acetonitrile; at 50 ℃; for 48h;

Reference yield:

: 1574541-77-7
methyl 2-(4-cyclopropylphenoxy)but-2-enoate

: 1574538-43-4
3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0 - 20 °C

2.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 6 h

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 12 h / 80 °C / Inert atmosphere

5.1: methanesulfonic acid / dichloromethane; methanol / 12 h / 20 °C

6.1: triethylamine / dichloromethane / 0 - 20 °C

7.1: sodium carbonate / acetonitrile / 48 h / 50 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methanesulfonic acid; lithium hydroxide monohydrate; water; sodium hydride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1574541-78-8
2-(4-cyclopropylphenoxy)but-2-enoic acid

: 1574538-43-4
3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 6 h

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 12 h / 80 °C / Inert atmosphere

4.1: methanesulfonic acid / dichloromethane; methanol / 12 h / 20 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: sodium carbonate / acetonitrile / 48 h / 50 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methanesulfonic acid; sodium hydride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;