7-benzyloxy-8-[1,3]dithian-2-yl-5-hydroxy-8-methyl-3-oxo-nonanoic acid tert-butyl ester

Base Information

Chemical Name:7-benzyloxy-8-[1,3]dithian-2-yl-5-hydroxy-8-methyl-3-oxo-nonanoic acid tert-butyl ester
CAS No.:335119-31-8
Molecular Formula:C₂₅H₃₈O₅S₂
Molecular Weight:482.706
Hs Code.:

Synonyms:7-benzyloxy-8-[1,3]dithian-2-yl-5-hydroxy-8-methyl-3-oxo-nonanoic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-benzyloxy-8-[1,3]dithian-2-yl-5-hydroxy-8-methyl-3-oxo-nonanoic acid tert-butyl ester

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Technology Process of 7-benzyloxy-8-[1,3]dithian-2-yl-5-hydroxy-8-methyl-3-oxo-nonanoic acid tert-butyl ester

There total 2 articles about 7-benzyloxy-8-[1,3]dithian-2-yl-5-hydroxy-8-methyl-3-oxo-nonanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 540-88-5
acetic acid tert-butyl ester

: 335119-28-3
5-benzyloxy-6-[1,3]dithian-2-yl-3-hydroxy-6-methyl-heptanoic acid methyl ester

: 335119-31-8
7-benzyloxy-8-[1,3]dithian-2-yl-5-hydroxy-8-methyl-3-oxo-nonanoic acid tert-butyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; for 2h;
DOI:10.1021/ol015551o

Reference yield:

: (4-benzyloxy-6-hydroxy-5,5-dimethyl-tetrahydro-pyran-2-yl)-acetic acid methyl ester

: 335119-31-8
7-benzyloxy-8-[1,3]dithian-2-yl-5-hydroxy-8-methyl-3-oxo-nonanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / BF₃*Et₂O / nitromethane / 0.5 h / -20 - -15 °C

2: 94 percent / LDA / tetrahydrofuran / 2 h / -78 - 0 °C

With boron trifluoride diethyl etherate; lithium diisopropyl amide; In tetrahydrofuran; nitromethane; 2: Claisen condensation;
DOI:10.1021/ol015551o

Reference yield:

: 335119-31-8
7-benzyloxy-8-[1,3]dithian-2-yl-5-hydroxy-8-methyl-3-oxo-nonanoic acid tert-butyl ester

: 7-benzyloxy-8-[1,3]dithian-2-yl-3,5-dihydroxy-8-methyl-nonanoic acid tert-butyl ester

: 7-benzyloxy-8-[1,3]dithian-2-yl-3,5-dihydroxy-8-methyl-nonanoic acid tert-butyl ester

Guidance literature:: With tetramethylammonium triacetoxyborohydride; In acetic acid; acetonitrile; at -35 - -25 ℃; for 96h; Title compound not separated from byproducts.;
DOI:10.1021/ol015551o